Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

255 drugs found

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Targets
Caprelsa
AstraZeneca
EGFR
VEGFR
Rivoceranib
Jiangsu Hengrui Medicine
VEGFR2
Xencor
SSTR2
CD3
Exelixis
KIT
VEGFR2
PDGFRB
Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK
Exelixis
PI3K Class I
Exelixis
IGF1R
Scr
FGFR
Bcr-Abl
Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2
HDAC (vorinostat)
26S proteasome (bortezomib)
Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)
Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R
Theseus
KIT
PDGFRa
Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta
Novartis
IGF-1R
FAK
Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)
Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)
Sutent + Stivarga
Pfizer + Bayer
Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET
Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)
Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR
Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl
Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl
Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)
Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)
Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB
Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)
Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)
Synta
HSP90
Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)
Serenex
HSP90
Rapamune
Wyeth
mTOR
cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3
Astex Pharmaceuticals
Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2
Schering-Plough
IGF1R
EMD Serono
Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK
Hoffman-La Roche
gama-secretase
Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)
Roche
MDM2
Afinitor/Certican
Novartis
mTOR
Hoffmann-La Roche
IGF1R
Topo/Target A/S
Oncothyreon
PI3K Class I
Oncothyreon
HIF-1α
Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB
Peloton
HIF-2a
Velcade
Millennium
26S proteasome
PharmaMar
Tubulin
Cogent Biosciences
KIT
FLT3
CSF-1R
Zelboraf
Plexxicon
BRAF V600E
Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R
Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR
Pfizer
Pfizer
Campostar
Pfizer
Novartis
PD-1
Ibrance
Pfizer
Cdk4
Cdk6
Pfizer
Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump
OSI
KIT
VEGFR
OSI
IGF1R
IR (insulin receptor)
Sandostatin
Novartis
SSTR
Novartis
IGF1R
Genentech
IDO1
Ningbo Newbay
KIT
PDGFRA
EMD Serono
EMD Serono
Hoffman-La Roche
PD-L1
Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)
Millenium
KIT
FLT3
PDGFRA
Zolinza
Merck
HDAC
HIF2A
Keytruda
Merck
PD-1
Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg
Merck
IGF1R
Novartis
PI3K Class 1A
MEK 1/2
Novartis
MEK 1/2
Medimmune
PD-L1
B7H1
MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)
Yervoy
Bristol-Myers Squibb
CTLA-4
Merck
ATR
Loxo Oncology
TrkA
TrkB
TrkC
NTRK
Novartis
KIT
Novartis
Farydak
Novartis
HDAC
Novartis
Kirin
IGF-1R
Kolltan
Kit
Keryx
AKT
Kura Oncology Inc
Menie-MLL
ISA Pharmaceuticals
Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)
Infinity
HSP90
Infinity
HSP90
Insmed
IGF1R
Incyte
IDO1
Incyte
Inhibrx, Inc.
DR5 (Death receptor 5)
DR5 (Death receptor 5)
Inhibrx, Inc.
DR5 (Death receptor 5)
ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)
ImClone
IGF-1R
ImClone
PDGFRA
Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)
Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB
Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3
Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl
Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)
Novartis
KIT (imatinib)
FGFR
IDRx, Inc.
KIT V654A
PDGFRa V651D
Stanford University
CD47
Novartis/Vernalis
Hsp90
Ascentage Pharma
Bcr-Abl
KIT
Aventis
Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3
TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K
Mekinist
GlaxoSmithKline
MEK1
MEK2

255 drugs found

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