Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

242 drugs found

Targets

Caprelsa
AstraZeneca
EGFR
VEGFR

Xencor
SSTR2
CD3

Exelixis
KIT
VEGFR2
PDGFRB

Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK

Exelixis
PI3K Class I

Exelixis
IGF1R
Scr
FGFR
Bcr-Abl

Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

HDAC (vorinostat)
26S proteasome (bortezomib)

Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Theseus
KIT
PDGFRa

Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta

Novartis
IGF-1R
FAK

Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)

Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)

Sutent + Stivarga
Pfizer + Bayer

Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET

Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)

Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR

Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl

Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl

Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)

Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)

Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB

Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)

Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)

Synta
HSP90

Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)

Serenex
HSP90

Rapamune
Wyeth
mTOR

cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3

Astex Pharmaceuticals

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Schering-Plough
IGF1R

EMD Serono

Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK

Hoffman-La Roche
gama-secretase

Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)

Roche
MDM2

Afinitor/Certican
Novartis
mTOR

Hoffmann-La Roche
IGF1R

Topo/Target A/S

Oncothyreon
PI3K Class I

Oncothyreon
HIF-1α

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB

Peloton
HIF-2a

Velcade
Millennium
26S proteasome


PharmaMar
Tubulin

Cogent Biosciences
KIT
FLT3
CSF-1R

Zelboraf
Plexxicon
BRAF V600E

Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R

Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR

Pfizer

Pfizer

Campostar
Pfizer

Novartis
PD-1

Ibrance
Pfizer
Cdk4
Cdk6

Pfizer

Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump

OSI
KIT
VEGFR

OSI
IGF1R
IR (insulin receptor)

Sandostatin
Novartis
SSTR

Novartis
IGF1R

Genentech
IDO1

Ningbo Newbay
KIT
PDGFRA

EMD Serono

EMD Serono

Hoffman-La Roche
PD-L1

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Millenium
KIT
FLT3
PDGFRA

Zolinza
Merck
HDAC

Keytruda
Merck
PD-1

Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg

Merck
IGF1R

Novartis
PI3K Class 1A
MEK 1/2

Novartis
MEK 1/2

Medimmune
PD-L1
B7H1

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)

Yervoy
Bristol-Myers Squibb
CTLA-4

Loxo Oncology
TrkA
TrkB
TrkC
NTRK

Novartis
KIT

Novartis

Farydak
Novartis
HDAC

Novartis

Kirin
IGF-1R

Kolltan
Kit

Keryx
AKT

ISA Pharmaceuticals

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)

Infinity
HSP90

Infinity
HSP90

Insmed
IGF1R

Incyte
IDO1

Incyte

Inhibrx, Inc.
DR5 (Death receptor 5)
DR5 (Death receptor 5)

Inhibrx, Inc.
DR5 (Death receptor 5)

ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)

ImClone
IGF-1R

ImClone
PDGFRA

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)

Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB

Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3

Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl

Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)

Novartis
KIT (imatinib)
FGFR

IDRx, Inc.
KIT V654A
PDGFRa V651D


Stanford University
CD47

Novartis/Vernalis
Hsp90

Ascentage Pharma
Bcr-Abl
KIT

Aventis


Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3

TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Mekinist
GlaxoSmithKline
MEK1
MEK2

GSK
IGF1R

Genentech/Piramed Ltd.
PI3K
mTOR

Genentech

Genentech/Exelixis
MEK

242 drugs found