Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

234 drugs found

Targets

OSI
KIT
VEGFR

Exelixis
KIT
VEGFR2
PDGFRB

Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor

Infinity
HSP90

AB Science
KIT
PDGFR
FGFR3
Lyn

Novartis
HSP90

Novartis
PI3K
mTOR

Biogen Idec
HSP90

Amgen
VEGFR1
VEGFR2
VEGFR3
KIT

Aventis

Bristol-Myers Squibb
VEGFR2
FGFR

Synta
HSP90

Oncothyreon
HIF-1α

Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)

Oncothyreon
PI3K Class I

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Piramed
PI3K Class 1

Serenex
HSP90

Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK

Infinity
HSP90

Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)

PDK
PDKII

Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR

Novartis
IGF-1R
FAK

Exelixis
PI3K Class I

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Hoffmann-La Roche
IGF1R

Novartis
PKC theta
PKC alpha
PKC beta

Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB


Keryx
AKT

Astex Therapeutics, Ltd.
HSP90


Novartis
PI3K Class 1

Novartis/Vernalis
Hsp90

Topo/Target A/S

Novartis
IGF1R

Bristol-Myers Squibb
IGF1R

Insmed
IGF1R

Exelixis
IGF1R
Scr
FGFR
Bcr-Abl

OSI
IGF1R
IR (insulin receptor)

GSK
IGF1R

Pfizer
IGF1R

ImClone
IGF-1R

Schering-Plough
IGF1R

Merck
IGF1R

Amgen
IGF1R

ChemGenex Pharmaceuticals
80S ribosome

Biogen Idec
IGF1R

Kirin
IGF-1R

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)


ARIAD
mTOR

Bristol-Myers Squibb
IGF-1R

Amgen
IGF-1R (AMG 479)
DR5 (Death receptor 5) (AMG 655)

ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)

HDAC (vorinostat)
26S proteasome (bortezomib)

Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB

Biogen Idec
HSP90

Millenium
KIT
FLT3
PDGFRA

Genentech/Piramed Ltd.
PI3K
mTOR

Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R

Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump

Genentech/Exelixis
MEK

Genentech
PI3K
MEK

EntreMed
Aurora Kinase A
Aurora Kinase B
VEGFR2
KIT
FGFR1

Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3

AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Array Biopharma/AstraZeneca
MEK 1/2

MEK 1/2
mTOR (CCI-779)

ImClone
PDGFRA


Roche
MDM2

Novartis
PI3K Class 1A

Novartis
MEK 1/2

Novartis
PI3K Class 1A
MEK 1/2

Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2

Novartis
PI3K Class 1
MEK 1/2

Hoffman-La Roche
gama-secretase

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)


Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)

Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A

GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)

Pfizer

Pfizer

Pfizer

EMD Serono

EMD Serono

EMD Serono

Genentech

Genentech

Bayer
PI3K

Bayer
MEK

Bayer
PI3K
MEK

Novartis



Novartis

Bristol-Myers Squibb
LAG-3

Bristol-Myers Squibb

GlaxoSmithKline

Incyte
IDO1

Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)

Novartis
FGFR
FGFR1
FGFR2
FGFR3

Novartis
KIT (imatinib)
FGFR

Calithera Biosciences, Inc
Glutaminase (GLS)

Boston Biomedical
NANOG

Novartis
KIT

Genentech
IDO1

Cogent Biosciences
KIT

Cogent Biosciences
KIT
FLT3
CSF-1R

Hoffman-La Roche
PD-L1

Hoffman-La Roche

Plexxicon + Merck

Novartis
PD-1

ISA Pharmaceuticals

Novartis

234 drugs found