Drug Detail

Information about TAS-116

Generic Name
IND
TAS-116
Brand Name (US)
Manufacturer
Taiho Pharmaceuticals
Drug Type
Kinase inhibitor
Delivery
Oral
Approval Status
Phase 2
Indications
Overall Strategy
KIT Protein + GIST cell based
Strategy
Destroy KIT
Drug Category
HSP90 inhibitor

TAS-116 is a HSP-90 inhibitor that may be more specific than older HSP-90 inhibiutors. It inhibits HSP-90 subtyeps alphas and beta, but not other HSP-90 paralogs such as endophasmic reticulum GRP94 or mitochondrial TRAP1 (NCI drug dictionary website). In therory, this may result in less off-target toxictiy allowing more treatment effect.