Generic Name |
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---|---|---|
IND |
TAS-116 | |
Brand Name (US) |
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Manufacturer |
Taiho Pharmaceuticals | |
Drug Type |
Kinase inhibitor | |
Delivery |
Oral | |
Approval Status |
Phase 2 | |
Indications |
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Overall Strategy |
KIT Protein + GIST cell based | |
Strategy |
Destroy KIT | |
Drug Category |
HSP90 inhibitor |
TAS-116 is a HSP-90 inhibitor that may be more specific than older HSP-90 inhibiutors. It inhibits HSP-90 subtyeps alphas and beta, but not other HSP-90 paralogs such as endophasmic reticulum GRP94 or mitochondrial TRAP1 (NCI drug dictionary website). In therory, this may result in less off-target toxictiy allowing more treatment effect.