Drug Detail

Information about Brostallicin

Generic Name	Brostallicin
IND	PNU-166196
Brand Name (US)
Manufacturer
Drug Type
Delivery
Approval Status	Phase 2
Indications
Overall Strategy	GIST Tumor Based
Strategy	Traditional chemotherapy
Drug Category	Chemotherapy

Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with antitumor activity in preclinical studies.
A phase II trial that included 21 GIST patients showed little response in GIST. Only 33% of the GIST patients had at least 3 months progression-free survival.