Drug Detail

Information about Brostallicin

Generic Name
Brostallicin
IND
PNU-166196
Brand Name (US)
Manufacturer
Drug Type
Delivery
Approval Status
Phase 2
Indications
Overall Strategy
GIST Tumor Based
Strategy
Traditional chemotherapy
Drug Category
Chemotherapy

Brostallicin (PNU-166196) is a cytotoxic agent that binds to the minor groove of DNA with antitumor activity in preclinical studies.
A phase II trial that included 21 GIST patients showed little response in GIST. Only 33% of the GIST patients had at least 3 months progression-free survival.