Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

235 drugs found

Targets

None, Adriamycin
Aventis,

Gemzar, Taxotere

Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells

Temodar
Schering-Plough
DNA methylation



Tasigna + Gleevec
Novartis

Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)

Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)

GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)

Novartis


GlaxoSmithKline

Gleevec + Dovitinib
Novartis

Hoffman-La Roche

Glivec + Stivarga
Novartis + Bayer

Plexxicon + Merck

Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4

Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2

Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1

Intuvax
Immunicum
CD8 and CD4 positive T-cells

Tumor antigens

BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR

MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R

PD-L1
CTLA-4

Merck + Incyte
PD-1
IDO1



BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K

Venclexta
Abbvie / Genetech
BCL-2

CStone Pharmaceuticals
PDL-1
KIT
PDGFRa

Pfizer
PD-L1
KIT

KIT
PDGFRa
XPO1

Taxol
Pfizer
Tubulin

Novartis
KIT
PD-1

Bayer, Merck
KIT
PD-L1

Stivarga
Bayer
MEK

Deciphera / Array

Advanced Accelerator Aplications
GRPR

AB Science
KIT
PDGFR
FGFR3
Lyn

Abbott
BCL-2

Novartis
PKC theta
PKC alpha
PKC beta

Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)

Advenchen Laboratories
KIT
PDGFRa
VEGFR2
VEGFR3

Amgen
IGF1R

Amgen
IGF-1R (AMG 479)
DR5 (Death receptor 5) (AMG 655)

Amgen
KRAS G12C

Amgen
VEGFR1
VEGFR2
VEGFR3
KIT

Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK

ARIAD
mTOR

Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2

ArQule
AKT

Astex Therapeutics, Ltd.
HSP90

Novartis
HSP90

AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB

Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB

Array Biopharma/AstraZeneca
MEK 1/2

MEK 1/2
mTOR (CCI-779)

Bayer
FGFR1
FGFR2
FGFR3
FGFR4

Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR

Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF

Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB

Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl

Bayer
PI3K

Bayer
PI3K
MEK

Bayer
MEK

Boston Biomedical
NANOG

Avastin
Genentech Bio-oncology
VEGF-A

Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor

Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2

BerGenBio
AXL

Novartis
FGFR
FGFR1
FGFR2
FGFR3

Novartis
PI3K
mTOR

Biogen Idec
IGF1R

Biogen Idec
HSP90

Biogen Idec
HSP90

Novartis
PI3K Class 1

Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A

Novartis
PI3K Class 1
MEK 1/2

AYVAKIT
Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V

Talzenna
Pfizer
PARP1
PARP2

Bristol-Myers Squibb
IGF1R

Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC

Bristol-Myers Squibb
VEGFR2
FGFR

Bristol-Myers Squibb
IGF-1R

Opdivo
Bristol-Myers Squibb
PD-1

Bristol-Myers Squibb

Bristol-Myers Squibb
LAG-3

Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)

Novartis
PI3K Class 1A

Calithera & Pfizer
Glutaminase (GLS)
PARP1
PARP2

Calithera Biosciences, Inc
Glutaminase (GLS)

Torisel
Wheth Pharmaceuticals
mTOR

Cogent Biosciences
KIT

ChemGenex Pharmaceuticals
80S ribosome

Pfizer
IGF1R

Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3

AstraZeneca
CTLA-4

Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)

Gleevec, Sutent
Daiichi Sankyo
DR5 (TRAIL-R2) (CS-1008)
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-abl
VEGFRs (sunitinib)
FLT3 (sunitinib)
CSF-1R (sunitinib)
RET (sunitinib)

CStone Pharmaceuticals
PD-L1

Ayvakit
Blueprint Medicines Corporation
PDGFRA (D842V)
KIT exon 17
KIT D816V

Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)

PDK
PDKII

QINLOCK
Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR2
TIE-2
Fms/CSF-1
BRAF
PDGFRB

Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl

Daichi Sanyo
TOPO-1
GPR20

Lenvima
Eisai Co.
KIT
PDGFRa
VEGFR1
VEGFR2
VEGFR3
RET
FGFR1
FGFR2
FGFR3
FGFR4

Mundipharma-EDO Gmbh
Histone-deacetylase


Edo

EntreMed
Aurora Kinase A
Aurora Kinase B
VEGFR2
KIT
FGFR1

Yondelis
Johnson & Johnson

Istodax
Gloucester Pharmaceuticals
HDAC

Genentech

Erivedge
Genentech
SMO (smoothened receptor)


Piramed
PI3K Class 1

Genentech
PI3K
MEK

Genentech/Exelixis
MEK

235 drugs found