Drug Detail

Information about NLG919

Generic Name
IND	NLG919
Brand Name (US)
Manufacturer	Genentech
Drug Type	IDO inhibitor
Delivery	Oral
Approval Status	Phase 1
Indications
Overall Strategy	Immune system
Strategy	Immunotherapy
Drug Category	IDO1 inhibitor

High IDO expression has been found in GIST tumors. IDO promotes the development, stabilization and activation of T reg cells and suppresses effector T cells (it acts as an immune system suppressor).
NLG919 is an oral small molecule inhibitor of the IDO pathway (indoleamine 2,3-dioxygenase).