Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

210 drugs found

Targets

Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB

Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET

Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl

Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V


Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2

Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR
TIE-2
Fms/CSF-1

Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK

Sutent + Stivarga
Pfizer + Bayer

Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR

Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3

Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC

Kolltan
Kit

AB Science
KIT
PDGFR
FGFR3
Lyn

Opdivo
Bristol-Myers Squibb
PD-1

Astex Pharmaceuticals

Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3

Bristol-Myers Squibb
LAG-3

Bristol-Myers Squibb

Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)

GlaxoSmithKline

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)

Rapamune
Wyeth
mTOR

Genentech/Piramed Ltd.
PI3K
mTOR

Ibrance
Pfizer
Cdk4
Cdk6

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)

Afinitor/Certican
Novartis
mTOR

Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl

Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4

Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2

Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1

Immunicum
CD8 and CD4 positive T-cells

Tumor antigens

ArQule
AKT

Ignyta
TrkA
TrkB
TrkC
ROS1
ALK

Loxo Oncology
TrkA
TrkB
TrkC

Abbott
BCL-2

BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR

Advanced Accelerator Aplications
GRPR

MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R

Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg

AstraZeneca
CTLA-4

PD-L1
CTLA-4

Merck + Incyte
PD-1
IDO1

Incyte

Mundipharma-EDO Gmbh
Histone-deacetylase

Xencor
SSTR2
CD3

PharmaMar
Tubulin


Plexxikon
KIT

Plexxikon
KIT
FLT3
CSF-1R

Hoffman-La Roche
PD-L1

Hoffman-La Roche

Glivec + Stivarga
Novartis + Bayer

Keytruda
Merck
PD-1

Plexxicon + Merck

Novartis
PD-1

ISA Pharmaceuticals

Novartis

Medimmune
PD-L1
B7H1

Stanford University
CD47

Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR

Calithera Biosciences, Inc
Glutaminase (GLS)

Gleevec + Dovitinib
Novartis

Boston Biomedical
NANOG

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB

Farydak
Novartis
HDAC

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)

Synta
HSP90

Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl

Novartis
KIT

Yervoy
Bristol-Myers Squibb
CTLA-4

Zolinza
Merck
HDAC

Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB

ARIAD
mTOR

BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K

Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)

Plexxicon Inc.
KIT
FLT3
Fms/CSF-1
CSF-1R

Zelboraf
Plexxicon Inc.
BRAF V600E

Oncothyreon
HIF-1α

OSI
IGF1R
IR (insulin receptor)

Caprelsa
AstraZeneca
EGFR
VEGFR

Novartis
PI3K
mTOR

Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)

Piramed
PI3K Class 1

Novartis
PI3K Class 1

AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB

Exelixis
PI3K Class I

Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)

Genentech
PI3K
MEK

Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB

Velcade
Millennium
26S proteasome

Tasigna + Gleevec
Novartis

OSI
KIT
VEGFR

ImClone
PDGFRA

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Torisel
Wheth Pharmaceuticals
mTOR

Novartis

Astex Therapeutics, Ltd.
HSP90

Incyte
IDO1

Novartis
HSP90

Genentech
IDO1

Novartis/Vernalis
Hsp90

Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)

GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl

ImClone
IGF-1R

Amgen
VEGFR1
VEGFR2
VEGFR3
KIT

Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)

Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells

Schering-Plough
IGF1R


Amgen
IGF1R

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)

ChemGenex Pharmaceuticals
80S ribosome

Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)

210 drugs found