Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

204 drugs found

Targets

Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB

Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET

Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl

Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V

Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2

Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR
TIE-2
Fms/CSF-1

Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK

Sutent + Stivarga
Pfizer + Bayer

Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR

Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3

Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC

Kolltan
Kit

AB Science
KIT
PDGFR
FGFR3
Lyn

Opdivo
Bristol-Myers Squibb
PD-1

Astex Pharmaceuticals

Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3

Bristol-Myers Squibb
LAG-3

Bristol-Myers Squibb

Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)

GlaxoSmithKline

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)

Rapamune
Wyeth
mTOR

Genentech/Piramed Ltd.
PI3K
mTOR

Ibrance
Pfizer
Cdk4
Cdk6

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)

Afinitor/Certican
Novartis
mTOR

Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl

Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4

Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2

Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1

Immunicum
CD8 and CD4 positive T-cells

Tumor antigens

ArQule
AKT

Ignyta
TrkA
TrkB
TrkC
ROS1
ALK

Loxo Oncology
TrkA
TrkB
TrkC

Abbott
BCL-2

BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR

Advanced Accelerator Aplications
GRPR

MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R

Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg

AstraZeneca
CTLA-4

PD-L1
CTLA-4

Merck + Incyte
PD-1
IDO1

Incyte

Mundipharma-EDO Gmbh
Histone-deacetylase

Plexxikon
KIT

Plexxikon
KIT
FLT3
CSF-1R

Hoffman-La Roche
PD-L1

Hoffman-La Roche

Glivec + Stivarga
Novartis + Bayer

Keytruda
Merck
PD-1

Plexxicon + Merck

Novartis
PD-1

ISA Pharmaceuticals

Novartis

Medimmune
PD-L1
B7H1

Stanford University
CD47

Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR

Calithera Biosciences, Inc
Glutaminase (GLS)

Gleevec + Dovitinib
Novartis

Boston Biomedical
NANOG

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB

Farydak
Novartis
HDAC

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)

Synta
HSP90

Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl

Novartis
KIT

Yervoy
Bristol-Myers Squibb
CTLA-4

Zolinza
Merck
HDAC

Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB

ARIAD
mTOR

Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)

Plexxicon Inc.
KIT
FLT3
Fms/CSF-1
CSF-1R

Zelboraf
Plexxicon Inc.
BRAF V600E

Oncothyreon
HIF-1α

OSI
IGF1R
IR (insulin receptor)

Caprelsa
AstraZeneca
EGFR
VEGFR

Novartis
PI3K
mTOR

Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)

Piramed
PI3K Class 1

Novartis
PI3K Class 1

AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB

Exelixis
PI3K Class I

Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)

Genentech
PI3K
MEK

Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB

Velcade
Millennium
26S proteasome

Tasigna + Gleevec
Novartis

OSI
KIT
VEGFR

ImClone
PDGFRA

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Torisel
Wheth Pharmaceuticals
mTOR

Novartis

Astex Therapeutics, Ltd.
HSP90

Incyte
IDO1

Novartis
HSP90

Genentech
IDO1

Novartis/Vernalis
Hsp90

Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)

GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl

ImClone
IGF-1R

Amgen
VEGFR1
VEGFR2
VEGFR3
KIT

Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)

Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells

Schering-Plough
IGF1R

Amgen
IGF1R

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)

ChemGenex Pharmaceuticals
80S ribosome

Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)

Novartis
PKC theta
PKC alpha
PKC beta

Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR

Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK

HDAC (vorinostat)
26S proteasome (bortezomib)

PDK
PDKII

Infinity
HSP90

204 drugs found