Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

232 drugs found

Targets

Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB

Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET

Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl

QINLOCK
Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR2
TIE-2
Fms/CSF-1
BRAF
PDGFRB

AYVAKIT
Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V


Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2

Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK

Sutent + Stivarga
Pfizer + Bayer

CStone Pharmaceuticals
PD-L1

CStone Pharmaceuticals
PDL-1
KIT
PDGFRa

Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR

Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3

Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC

Kolltan
Kit

AB Science
KIT
PDGFR
FGFR3
Lyn

Opdivo
Bristol-Myers Squibb
PD-1

Astex Pharmaceuticals

Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3

Bristol-Myers Squibb
LAG-3

Bristol-Myers Squibb

Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)

GlaxoSmithKline

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)

Rapamune
Wyeth
mTOR

Genentech/Piramed Ltd.
PI3K
mTOR

Pfizer
PD-L1
KIT

Ayvakit
Blueprint Medicines Corporation
PDGFRA (D842V)
KIT exon 17
KIT D816V

Lenvima
Eisai Co.
KIT
PDGFRa
VEGFR1
VEGFR2
VEGFR3
RET
FGFR1
FGFR2
FGFR3
FGFR4

KIT
PDGFRa
XPO1

Advenchen Laboratories
KIT
PDGFRa
VEGFR2
VEGFR3

Taxol
Pfizer
Tubulin

Novartis
KIT
PD-1

Ascentage Pharma
Bcr-Abl
KIT

Bayer, Merck
KIT
PD-L1

Stivarga
Bayer
MEK

Daichi Sanyo
TOPO-1
GPR20

Bayer
FGFR1
FGFR2
FGFR3
FGFR4

Ibrance
Pfizer
Cdk4
Cdk6

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)

Afinitor/Certican
Novartis
mTOR

Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl

Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4

Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2

Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1

Intuvax
Immunicum
CD8 and CD4 positive T-cells

Tumor antigens

ArQule
AKT

Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK

Loxo Oncology
TrkA
TrkB
TrkC
NTRK

Abbott
BCL-2

BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR

Advanced Accelerator Aplications
GRPR

MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R

Venclexta
Abbvie / Genetech
BCL-2

Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg

AstraZeneca
CTLA-4

PD-L1
CTLA-4

Merck + Incyte
PD-1
IDO1

Incyte

Mundipharma-EDO Gmbh
Histone-deacetylase

Xencor
SSTR2
CD3

PharmaMar
Tubulin


Edo

Peloton
HIF-2a

Talzenna
Pfizer
PARP1
PARP2

Calithera & Pfizer
Glutaminase (GLS)
PARP1
PARP2

Unum Therapeutics
KIT

Amgen
KRAS G12C

Plexxikon
KIT
FLT3
CSF-1R

Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta

Hoffman-La Roche
PD-L1

Hoffman-La Roche

Glivec + Stivarga
Novartis + Bayer

Keytruda
Merck
PD-1

Plexxicon + Merck

Novartis
PD-1

ISA Pharmaceuticals

Novartis

Medimmune
PD-L1
B7H1

Stanford University
CD47

Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR

Calithera Biosciences, Inc
Glutaminase (GLS)

Gleevec + Dovitinib
Novartis

Boston Biomedical
NANOG

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB

Farydak
Novartis
HDAC

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)

Synta
HSP90

Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl

Novartis
KIT

Yervoy
Bristol-Myers Squibb
CTLA-4

Zolinza
Merck
HDAC

Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB

ARIAD
mTOR

BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K

Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)

Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R

Zelboraf
Plexxicon
BRAF V600E

Oncothyreon
HIF-1α

OSI
IGF1R
IR (insulin receptor)

Caprelsa
AstraZeneca
EGFR
VEGFR

Novartis
PI3K
mTOR

Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)

Piramed
PI3K Class 1

Novartis
PI3K Class 1

AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB

Exelixis
PI3K Class I

Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)

Genentech
PI3K
MEK

Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB

Velcade
Millennium
26S proteasome

Tasigna + Gleevec
Novartis

OSI
KIT
VEGFR

ImClone
PDGFRA

232 drugs found