Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

235 drugs found

Targets

OSI
KIT
VEGFR

Exelixis
KIT
VEGFR2
PDGFRB

Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor

Infinity
HSP90

Novartis
HSP90

Novartis
PI3K
mTOR

Oncothyreon
HIF-1α

Oncothyreon
PI3K Class I

Serenex
HSP90

Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK

Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)

Exelixis
PI3K Class I

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Hoffmann-La Roche
IGF1R

Novartis
PI3K Class 1

Novartis/Vernalis
Hsp90

Novartis
IGF1R

Bristol-Myers Squibb
IGF1R

Insmed
IGF1R

Exelixis
IGF1R
Scr
FGFR
Bcr-Abl

GSK
IGF1R

Schering-Plough
IGF1R

Merck
IGF1R

Amgen
IGF1R

Biogen Idec
IGF1R

Kirin
IGF-1R

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)

Bristol-Myers Squibb
IGF-1R

Amgen
IGF-1R (AMG 479)
DR5 (Death receptor 5) (AMG 655)

HDAC (vorinostat)
26S proteasome (bortezomib)

Biogen Idec
HSP90

Genentech/Piramed Ltd.
PI3K
mTOR

Genentech
PI3K
MEK

EntreMed
Aurora Kinase A
Aurora Kinase B
VEGFR2
KIT
FGFR1

MEK 1/2
mTOR (CCI-779)


Roche
MDM2

Novartis
PI3K Class 1A

Novartis
PI3K Class 1A
MEK 1/2

Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2

Novartis
PI3K Class 1
MEK 1/2

Hoffman-La Roche
gama-secretase

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)


Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)

Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A

Pfizer

Pfizer

Pfizer

EMD Serono

EMD Serono

Genentech

Genentech

Bayer
PI3K

Bayer
MEK

Bayer
PI3K
MEK

Novartis

Bristol-Myers Squibb
LAG-3

Incyte
IDO1

Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)

Novartis
FGFR
FGFR1
FGFR2
FGFR3

Novartis
KIT (imatinib)
FGFR

Boston Biomedical
NANOG

Novartis
KIT

Genentech
IDO1

Cogent Biosciences
KIT

Hoffman-La Roche
PD-L1

Novartis
PD-1

ISA Pharmaceuticals

Novartis

Stanford University
CD47

Kolltan
Kit

ArQule
AKT

BerGenBio
AXL

Xencor
SSTR2
CD3

Peloton
HIF-2a

Amgen
KRAS G12C

Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta

CStone Pharmaceuticals
PD-L1

CStone Pharmaceuticals
PDL-1
KIT
PDGFRa

Ascentage Pharma
Bcr-Abl
KIT

Daichi Sanyo
TOPO-1
GPR20

Ningbo Newbay
KIT
PDGFRA

Advenchen Laboratories
KIT
PDGFRa
VEGFR2
VEGFR3

AYVAKIT
Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V

Ayvakit
Blueprint Medicines Corporation
PDGFRA (D842V)
KIT exon 17
KIT D816V


Pfizer
PD-L1
KIT

Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)

Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1

Topo/Target A/S

Avastin
Genentech Bio-oncology
VEGF-A

Novartis
MEK 1/2

MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R

Velcade
Millennium
26S proteasome

Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)

Bristol-Myers Squibb
VEGFR2
FGFR


Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB

ImClone
IGF-1R

ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)

Biogen Idec
HSP90

Genentech/Exelixis
MEK

Hoffman-La Roche


Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3

Gleevec, Sutent
Daiichi Sankyo
DR5 (TRAIL-R2) (CS-1008)
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-abl
VEGFRs (sunitinib)
FLT3 (sunitinib)
CSF-1R (sunitinib)
RET (sunitinib)

Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2

TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC

Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)

Tumor antigens

PDK
PDKII

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl

Medimmune
PD-L1
B7H1

PD-L1
CTLA-4

BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K

235 drugs found