Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

235 drugs found

Targets

PDK
PDKII

Gemzar, Taxotere




HDAC (vorinostat)
26S proteasome (bortezomib)

MEK 1/2
mTOR (CCI-779)





Tumor antigens

BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR

MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R

Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg

PD-L1
CTLA-4




KIT
PDGFRa
XPO1

cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3

AB Science
KIT
PDGFR
FGFR3
Lyn

Abbott
BCL-2

Venclexta
Abbvie / Genetech
BCL-2

Advanced Accelerator Aplications
GRPR

Advenchen Laboratories
KIT
PDGFRa
VEGFR2
VEGFR3

Amgen
VEGFR1
VEGFR2
VEGFR3
KIT

Amgen
IGF1R

Amgen
IGF-1R (AMG 479)
DR5 (Death receptor 5) (AMG 655)

Amgen
KRAS G12C

ARIAD
mTOR

Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2

Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3

ArQule
AKT

BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K

Array Biopharma/AstraZeneca
MEK 1/2

Ascentage Pharma
Bcr-Abl
KIT

Astex Pharmaceuticals

Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)

Astex Therapeutics, Ltd.
HSP90

Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB

Caprelsa
AstraZeneca
EGFR
VEGFR

AstraZeneca
CTLA-4

Aventis

None, Adriamycin
Aventis,

AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB

Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl

Bayer
PI3K

Bayer
MEK

Bayer
PI3K
MEK

Stivarga
Bayer
MEK

Bayer
FGFR1
FGFR2
FGFR3
FGFR4

Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR

Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF

Bayer, Merck
KIT
PD-L1

Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB

BerGenBio
AXL

Biogen Idec
HSP90

Biogen Idec
IGF1R

Biogen Idec
HSP90

AYVAKIT
Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V

Ayvakit
Blueprint Medicines Corporation
PDGFRA (D842V)
KIT exon 17
KIT D816V

Boston Biomedical
NANOG

Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)

Bristol-Myers Squibb
VEGFR2
FGFR

Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC

Bristol-Myers Squibb
IGF1R

Bristol-Myers Squibb
IGF-1R

Yervoy
Bristol-Myers Squibb
CTLA-4

Opdivo
Bristol-Myers Squibb
PD-1

Bristol-Myers Squibb
LAG-3

Bristol-Myers Squibb

Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)

Calithera & Pfizer
Glutaminase (GLS)
PARP1
PARP2

Calithera Biosciences, Inc
Glutaminase (GLS)

ChemGenex Pharmaceuticals
80S ribosome

Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells

Cogent Biosciences
KIT

Cogent Biosciences
KIT
FLT3
CSF-1R

Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)

CStone Pharmaceuticals
PD-L1

CStone Pharmaceuticals
PDL-1
KIT
PDGFRa

Daichi Sanyo
TOPO-1
GPR20

Gleevec, Sutent
Daiichi Sankyo
DR5 (TRAIL-R2) (CS-1008)
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-abl
VEGFRs (sunitinib)
FLT3 (sunitinib)
CSF-1R (sunitinib)
RET (sunitinib)

Deciphera / Array

QINLOCK
Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR2
TIE-2
Fms/CSF-1
BRAF
PDGFRB

Edo

Lenvima
Eisai Co.
KIT
PDGFRa
VEGFR1
VEGFR2
VEGFR3
RET
FGFR1
FGFR2
FGFR3
FGFR4

EMD Serono

EMD Serono

EMD Serono

EntreMed
Aurora Kinase A
Aurora Kinase B
VEGFR2
KIT
FGFR1

Exelixis
KIT
VEGFR2
PDGFRB

Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK

Exelixis
PI3K Class I

Exelixis
IGF1R
Scr
FGFR
Bcr-Abl

Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

Genentech
PI3K
MEK

Erivedge
Genentech
SMO (smoothened receptor)

Genentech

Genentech

Genentech
IDO1

Avastin
Genentech Bio-oncology
VEGF-A

Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)

Genentech/Exelixis
MEK

Genentech/Piramed Ltd.
PI3K
mTOR

Mekinist
GlaxoSmithKline
MEK1
MEK2

GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)

GlaxoSmithKline

Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2

Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3

Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)

TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)

Istodax
Gloucester Pharmaceuticals
HDAC

GSK
IGF1R

Hoffman-La Roche
gama-secretase

Hoffman-La Roche
PD-L1

Hoffman-La Roche

235 drugs found