Drug Detail

Information about RG7112

Generic Name
IND	RG7112
Brand Name (US)
Manufacturer	Roche
Drug Type	Small molecule
Delivery	Oral
Approval Status	Phase 1
Indications
Overall Strategy	GIST cell based
Strategy	Unblock cell death genes
Drug Category	MDM2 inhibitor

The p53 tumor suppressor is a poten growth suppressive and pro-apoptic molecule that is frequently inhibited in cancer cells by overproduction of MDM2. Inhibitors of the p53-MDM2 interaction can release p53 from negative control and restore its antitumor activity.