Drug Detail

Information about Rapamune

Generic Name	Sirolimus
IND	Sirolimus
Brand Name (US)	Rapamune
Manufacturer	Wyeth
Drug Type	mTOR inhibitor
Delivery	Oral
Approval Status	Approved for a non-GIST application
Indications	Kidney transplant
Overall Strategy	Oncogenic Signal Path Based
Strategy	Block KIT Signal Path
Drug Category	mTOR inhibitor

Sirolimus is often called "rapamycin". It was the first mTOR inhibitor approved in the United States. It is approved for treatment against organ transplant rejection.
MTOR inhibitors have anti-tumor properties and a number of them are being tried in clinical trials.
Sirolimus has been used by some GIST patients in an "off-label" fashion. It is not approved for GIST and is not in any GIST trials (as of 2008).