Drug Detail

Information about MEDI-573

Generic Name
IND	MEDI-573
Brand Name (US)
Manufacturer	MedImmune LLC
Drug Type	monoclonal antibody
Delivery	Intravenous
Approval Status	Phase 2
Indications
Overall Strategy	GIST cell based
Strategy	Block related tumor signal paths
Drug Category	IGF1R inhibitor

This is a monoclonal antibody that binds to the IGF-1 and IGF-II ligands. These ligands (growth factors) normally would bind to and activate the IGF-1R and IR-A receptor.
IGF-1R signaling has been implicated in about 2/3 of patients with wild-type GIST and in patients with pediatric GIST (which is also wild-type).