Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

249 drugs found

Targets

Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)

TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)

Istodax
Gloucester Pharmaceuticals
HDAC

GSK
IGF1R

Hoffman-La Roche
gama-secretase

Hoffman-La Roche
PD-L1

Hoffman-La Roche

Hoffmann-La Roche
IGF1R

IDRx, Inc.
KIT V654A
PDGFRa V651D

Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK

ImClone
IGF-1R

ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)

ImClone
PDGFRA

Intuvax
Immunicum
CD8 and CD4 positive T-cells

Incyte
IDO1

Incyte

Infinity
HSP90

Infinity
HSP90

Inhibrx, Inc.
DR5 (Death receptor 5)

Inhibrx, Inc.
DR5 (Death receptor 5)
DR5 (Death receptor 5)

Insmed
IGF1R

ISA Pharmaceuticals

Rivoceranib
Jiangsu Hengrui Medicine
VEGFR2

Yondelis
Johnson & Johnson

Keryx
AKT

Kirin
IGF-1R

Kolltan
Kit

Loxo Oncology
TrkA
TrkB
TrkC
NTRK

Medimmune
PD-L1
B7H1

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)

Zolinza
Merck
HDAC

Merck
IGF1R

Keytruda
Merck
PD-1

Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)

Merck + Incyte
PD-1
IDO1

Millenium
KIT
FLT3
PDGFRA

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Velcade
Millennium
26S proteasome

Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)

Mundipharma-EDO Gmbh
Histone-deacetylase

Ningbo Newbay
KIT
PDGFRA

Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK

Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor

Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB

Novartis
HSP90

Novartis
PI3K
mTOR

Farydak
Novartis
HDAC

Afinitor/Certican
Novartis
mTOR

Sandostatin
Novartis
SSTR

Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)

Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR

Novartis
IGF-1R
FAK

Novartis
PKC theta
PKC alpha
PKC beta

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB

Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3

Novartis
PI3K Class 1

Novartis
IGF1R

Tasigna + Gleevec
Novartis

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Novartis
PI3K Class 1A

Novartis
MEK 1/2

Novartis
PI3K Class 1A
MEK 1/2

Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2

Novartis
PI3K Class 1
MEK 1/2

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)

Novartis

Novartis

Novartis
FGFR
FGFR1
FGFR2
FGFR3

Novartis
KIT (imatinib)
FGFR

Gleevec + Dovitinib
Novartis

Novartis
KIT

Novartis
PD-1

Novartis

Novartis
KIT
PD-1

Glivec + Stivarga
Novartis + Bayer

Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)

Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)

Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A

Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl

Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)

Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB

Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl

Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)

Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR

Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)

Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl

Novartis/Vernalis
Hsp90

Oncothyreon
HIF-1α

Oncothyreon
PI3K Class I

OSI
KIT
VEGFR

OSI
IGF1R
IR (insulin receptor)

Peloton
HIF-2a

Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET

Pfizer
IGF1R

Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)

Pfizer

Pfizer

Campostar
Pfizer

Pfizer

Ibrance
Pfizer
Cdk4
Cdk6

Talzenna
Pfizer
PARP1
PARP2

Pfizer
PD-L1
KIT

Taxol
Pfizer
Tubulin

Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1

Sutent + Stivarga
Pfizer + Bayer

Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)

Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)

Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl

PharmaMar
Tubulin

Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump

Piramed
PI3K Class 1

Zelboraf
Plexxicon
BRAF V600E

Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R

Plexxicon + Merck

Roche
MDM2

Temodar
Schering-Plough
DNA methylation

Schering-Plough
IGF1R

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Serenex
HSP90

249 drugs found