Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
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265 drugs found

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Targets
Avastin
Genentech Bio-oncology
VEGF-A
Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)
Genentech/Exelixis
MEK
Genentech/Piramed Ltd.
PI3K
mTOR
Mekinist
GlaxoSmithKline
MEK1
MEK2
GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)
GlaxoSmithKline
Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2
Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3
Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)
TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K
Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)
Istodax
Gloucester Pharmaceuticals
HDAC
GSK
IGF1R
Hoffman-La Roche
gama-secretase
Hoffman-La Roche
PD-L1
Hoffman-La Roche
Hoffmann-La Roche
IGF1R
IDRx, Inc.
KIT V654A
PDGFRa V651D
Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK
ImClone
IGF-1R
ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)
ImClone
PDGFRA
Intuvax
Immunicum
CD8 and CD4 positive T-cells
Incyte
IDO1
Incyte
Pemazyre
Incyte
FGFR2
Infinity
HSP90
Infinity
HSP90
Inhibrx, Inc.
DR5 (Death receptor 5)
Inhibrx, Inc.
DR5 (Death receptor 5)
DR5 (Death receptor 5)
Tyvyt
Innovent
PD-1
Insmed
IGF1R
ISA Pharmaceuticals
Rivoceranib
Jiangsu Hengrui Medicine
VEGFR2
Yondelis
Johnson & Johnson
Keryx
AKT
Kirin
IGF-1R
Kolltan
Kit
Kumquat Biosciences
SOS1
Komzifti
Kura Oncology Inc
Menie-MLL
Loxo Oncology
TrkA
TrkB
TrkC
NTRK
Medimmune
PD-L1
B7H1
MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)
Zolinza
Merck
HDAC
Merck
IGF1R
Keytruda
Merck
PD-1
Merck
ATR
Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)
Merck + Incyte
PD-1
IDO1
Millenium
KIT
FLT3
PDGFRA
Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)
Velcade
Millennium
26S proteasome
Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)
Mundipharma-EDO Gmbh
Histone-deacetylase
Ningbo Newbay
KIT
PDGFRA
Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK
Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor
Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB
Novartis
HSP90
Novartis
PI3K
mTOR
Farydak
Novartis
HDAC
Afinitor/Certican
Novartis
mTOR
Sandostatin
Novartis
SSTR
Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)
Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR
Novartis
IGF-1R
FAK
Novartis
PKC theta
PKC alpha
PKC beta
Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB
Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3
Novartis
PI3K Class 1
Novartis
IGF1R
Tasigna + Gleevec
Novartis
Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R
Novartis
PI3K Class 1A
Novartis
MEK 1/2
Novartis
PI3K Class 1A
MEK 1/2
Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2
Novartis
PI3K Class 1
MEK 1/2
Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)
Novartis
Novartis
Novartis
FGFR
FGFR1
FGFR2
FGFR3
VEGFR2
Novartis
KIT (imatinib)
FGFR
Gleevec + Dovitinib
Novartis
Novartis
KIT
Novartis
PD-1
Novartis
Novartis
KIT
PD-1
Novartis
FGFR
FGFR1
FGFR2
FFGFR3
KIT
PDGFRA
VEGFR2
Glivec + Stivarga
Novartis + Bayer
Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)
Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)
Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A
Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl
Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)
Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB
Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl
Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)
Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR
Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)
Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl
Novartis/Vernalis
Hsp90
Novelty Nobility
KIT
Oncothyreon
HIF-1α
Oncothyreon
PI3K Class I
OSI
KIT
VEGFR
OSI
IGF1R
IR (insulin receptor)
Peloton
HIF-2a
Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET
Pfizer
IGF1R
Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)
Pfizer
Pfizer
Campostar
Pfizer
Pfizer
Ibrance
Pfizer
Cdk4
Cdk6
Talzenna
Pfizer
PARP1
PARP2
Pfizer
PD-L1
KIT
Taxol
Pfizer
Tubulin

265 drugs found

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