Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
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259 drugs found

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Targets
Genentech/Piramed Ltd.
PI3K
mTOR
Mekinist
GlaxoSmithKline
MEK1
MEK2
GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)
GlaxoSmithKline
Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2
Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3
Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)
TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K
Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)
Istodax
Gloucester Pharmaceuticals
HDAC
GSK
IGF1R
Hoffman-La Roche
gama-secretase
Hoffman-La Roche
PD-L1
Hoffman-La Roche
Hoffmann-La Roche
IGF1R
IDRx, Inc.
KIT V654A
PDGFRa V651D
Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK
ImClone
IGF-1R
ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)
ImClone
PDGFRA
Intuvax
Immunicum
CD8 and CD4 positive T-cells
Incyte
IDO1
Incyte
Infinity
HSP90
Infinity
HSP90
Inhibrx, Inc.
DR5 (Death receptor 5)
Inhibrx, Inc.
DR5 (Death receptor 5)
DR5 (Death receptor 5)
Insmed
IGF1R
ISA Pharmaceuticals
Rivoceranib
Jiangsu Hengrui Medicine
VEGFR2
Yondelis
Johnson & Johnson
Keryx
AKT
Kirin
IGF-1R
Kolltan
Kit
Kura Oncology Inc
Menie-MLL
Loxo Oncology
TrkA
TrkB
TrkC
NTRK
Medimmune
PD-L1
B7H1
MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)
Zolinza
Merck
HDAC
Merck
IGF1R
Keytruda
Merck
PD-1
Merck
ATR
Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)
Merck + Incyte
PD-1
IDO1
Millenium
KIT
FLT3
PDGFRA
Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)
Velcade
Millennium
26S proteasome
Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)
Mundipharma-EDO Gmbh
Histone-deacetylase
Ningbo Newbay
KIT
PDGFRA
Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK
Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor
Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB
Novartis
HSP90
Novartis
PI3K
mTOR
Farydak
Novartis
HDAC
Afinitor/Certican
Novartis
mTOR
Sandostatin
Novartis
SSTR
Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)
Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR
Novartis
IGF-1R
FAK
Novartis
PKC theta
PKC alpha
PKC beta
Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB
Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3
Novartis
PI3K Class 1
Novartis
IGF1R
Tasigna + Gleevec
Novartis
Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R
Novartis
PI3K Class 1A
Novartis
MEK 1/2
Novartis
PI3K Class 1A
MEK 1/2
Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2
Novartis
PI3K Class 1
MEK 1/2
Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)
Novartis
Novartis
Novartis
FGFR
FGFR1
FGFR2
FGFR3
VEGFR2
Novartis
KIT (imatinib)
FGFR
Gleevec + Dovitinib
Novartis
Novartis
KIT
Novartis
PD-1
Novartis
Novartis
KIT
PD-1
Novartis
FGFR
FGFR1
FGFR2
FFGFR3
KIT
PDGFRA
VEGFR2
Glivec + Stivarga
Novartis + Bayer
Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)
Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)
Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A
Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl
Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)
Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB
Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl
Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)
Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR
Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)
Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl
Novartis/Vernalis
Hsp90
Novelty Nobility
KIT
Oncothyreon
HIF-1α
Oncothyreon
PI3K Class I
OSI
KIT
VEGFR
OSI
IGF1R
IR (insulin receptor)
Peloton
HIF-2a
Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET
Pfizer
IGF1R
Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)
Pfizer
Pfizer
Campostar
Pfizer
Pfizer
Ibrance
Pfizer
Cdk4
Cdk6
Talzenna
Pfizer
PARP1
PARP2
Pfizer
PD-L1
KIT
Taxol
Pfizer
Tubulin
Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1
Sutent + Stivarga
Pfizer + Bayer
Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)
Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)
Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl
PharmaMar
Tubulin

259 drugs found

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