Drug Detail

Information about GSK 621659A

Generic Name
IND	GSK 621659A
Brand Name (US)
Manufacturer	GSK
Drug Type	Tyrosine Kinase Inhibitor
Delivery	Oral
Approval Status	Preclinical
Indications
Overall Strategy	GIST cell based
Strategy	Block related tumor signal paths
Drug Category	IGF1R inhibitor

This is a IGF1R inhibitor in early development. IGF1R is overexpressed in 2/3 of wild-type GISTs and almost all pediatric GISTs.
Patients with wild-type GIST and pediatric GIST may be good candidates for a trial with inhibitors of IGF1R.