Generic Name |
Infigratinib + Imatinib | |
---|---|---|
IND |
||
Brand Name (US) |
||
Manufacturer |
Novartis | |
Drug Type |
||
Delivery |
Oral | |
Approval Status |
Infigratinib Discontinued development in GIST | |
Indications |
||
Overall Strategy |
KIT Protein Based + Oncogenic Signal Path Based | |
Strategy |
Block KIT & Block FGFR | |
Drug Category |
FGFR + KIT/PDGFRA inhibitor |
BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2. (From: Selleckchem)