Drug Detail

Information about Sotrastaurin

Generic Name	Sotrastaurin
IND	AEB071
Brand Name (US)
Manufacturer	Novartis
Drug Type	Tyrosine Kinase Inhibitor
Delivery	Oral
Approval Status	Phase 2
Indications
Overall Strategy	GIST cell based
Strategy	Block KIT Signal Path
Drug Category	PKC theta inhibitor

AEB071 is a novel PKC inhibitor that has strong and specific activity on PKCθ, PKCα, and PKCβ and lesser activity on PKCδ, PKCε, and PKCη, suggesting that AEB071 would inhibit not only T cells, but also a variety of other cells. It is selective for more than 200 other kinases, including those important for early T cell activation, such as lck and ZAP-70.