Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
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246 drugs found

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Targets
Genentech
Erivedge
Genentech
SMO (smoothened receptor)
Piramed
PI3K Class 1
Genentech
PI3K
MEK
Genentech/Exelixis
MEK
Genentech
Genentech/Piramed Ltd.
PI3K
mTOR
GSK
IGF1R
Mekinist
GlaxoSmithKline
MEK1
MEK2
TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K
Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3
Aventis
Ascentage Pharma
Bcr-Abl
KIT
Novartis/Vernalis
Hsp90
Stanford University
CD47
IDRx, Inc.
KIT V654A
PDGFRa V651D
Novartis
KIT (imatinib)
FGFR
Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)
Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl
Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3
Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB
Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)
ImClone
PDGFRA
ImClone
IGF-1R
ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)
Inhibrx, Inc.
DR5 (Death receptor 5)
Inhibrx, Inc.
DR5 (Death receptor 5)
DR5 (Death receptor 5)
Incyte
Incyte
IDO1
Insmed
IGF1R
Infinity
HSP90
Infinity
HSP90
Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)
ISA Pharmaceuticals
Keryx
AKT
Kolltan
Kit
Kirin
IGF-1R
Novartis
Farydak
Novartis
HDAC
Novartis
Novartis
KIT
Loxo Oncology
TrkA
TrkB
TrkC
NTRK
Yervoy
Bristol-Myers Squibb
CTLA-4
MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)
Medimmune
PD-L1
B7H1
Novartis
MEK 1/2
Novartis
PI3K Class 1A
MEK 1/2
Merck
IGF1R
Keytruda
Merck
PD-1
Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg
HIF2A
Zolinza
Merck
HDAC
Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)
Millenium
KIT
FLT3
PDGFRA
Hoffman-La Roche
PD-L1
EMD Serono
EMD Serono
Ningbo Newbay
KIT
PDGFRA
Genentech
IDO1
Novartis
IGF1R
Sandostatin
Novartis
SSTR
OSI
IGF1R
IR (insulin receptor)
OSI
KIT
VEGFR
Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump
Pfizer
Ibrance
Pfizer
Cdk4
Cdk6
Novartis
PD-1
Campostar
Pfizer
Pfizer
Pfizer
Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR
Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R
Zelboraf
Plexxicon
BRAF V600E
Cogent Biosciences
KIT
FLT3
CSF-1R
PharmaMar
Tubulin
Velcade
Millennium
26S proteasome
Peloton
HIF-2a
Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB
Oncothyreon
HIF-1α
Oncothyreon
PI3K Class I
Topo/Target A/S
Hoffmann-La Roche
IGF1R
Afinitor/Certican
Novartis
mTOR
Roche
MDM2
Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)
Hoffman-La Roche
gama-secretase
Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK
EMD Serono
Schering-Plough
IGF1R
Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2
Astex Pharmaceuticals
cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3
Rapamune
Wyeth
mTOR
Serenex
HSP90
Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)
Synta
HSP90
Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)
Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)
Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB
Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)
Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)
Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl
Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl
Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR
Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)
Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET
Sutent + Stivarga
Pfizer + Bayer
Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)
Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)
Novartis
IGF-1R
FAK
Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta
Theseus
KIT
PDGFRa
Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R
Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)
HDAC (vorinostat)
26S proteasome (bortezomib)
Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

246 drugs found

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