Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
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255 drugs found

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Targets
Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)
Deciphera
ULK1/2
KIT
Tumor antigens
PDK
PDKII
Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R
Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl
Medimmune
PD-L1
B7H1
PD-L1
CTLA-4
BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K
Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK
Incyte
Afinitor/Certican
Novartis
mTOR
cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3
Pfizer
IGF1R
None, Adriamycin
Aventis,
Aventis
Synta
HSP90
Gemzar, Taxotere
Astex Pharmaceuticals
Intuvax
Immunicum
CD8 and CD4 positive T-cells
Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB
Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)
Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)
KIT
PDGFRa
PD-L1
Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)
Novartis
Gleevec + Dovitinib
Novartis
Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR
Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)
Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3
Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)
Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl
Novartis
KIT
PD-1
Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl
Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl
Glivec + Stivarga
Novartis + Bayer
KIT
PDGFRa
XPO1
Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)
Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB
Novartis
FGFR
FGFR1
FGFR2
FGFR3
VEGFR2
Novartis
FGFR
FGFR1
FGFR2
FFGFR3
KIT
PDGFRA
VEGFR2
Yervoy
Bristol-Myers Squibb
CTLA-4
Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)
Campostar
Pfizer
Loxo Oncology
TrkA
TrkB
TrkC
NTRK
Lenvima
Eisai Co.
KIT
PDGFRa
VEGFR1
VEGFR2
VEGFR3
RET
FGFR1
FGFR2
FGFR3
FGFR4
OSI
IGF1R
IR (insulin receptor)
Liporaxel
Dae Hwa Pharmaceutical
Tubulin
AB Science
KIT
PDGFR
FGFR3
Lyn
Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR
Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells
Amgen
VEGFR1
VEGFR2
VEGFR3
KIT
Abbott
BCL-2
BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR
Advanced Accelerator Aplications
GRPR
Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK
Tasigna + Gleevec
Novartis
Opdivo
Bristol-Myers Squibb
PD-1
Bristol-Myers Squibb
Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4
Sandostatin
Novartis
SSTR
ImClone
PDGFRA
Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump
Ascentage Pharma
Bcr-Abl
KIT
ChemGenex Pharmaceuticals
80S ribosome
Astex Therapeutics, Ltd.
HSP90
Taxol
Pfizer
Tubulin
Ibrance
Pfizer
Cdk4
Cdk6
Farydak
Novartis
HDAC
Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)
Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3
Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)
GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)
Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)
Keytruda
Merck
PD-1
Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg
Merck + Incyte
PD-1
IDO1
Keryx
AKT
Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R
Piramed
PI3K Class 1
EMD Serono
Taiho Phrmaceutical Co.
PharmaMar
Tubulin
Plexxicon + Merck
Cogent Biosciences
KIT
FLT3
CSF-1R
Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2
Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl
Stivarga
Bayer
MEK
Bayer, Merck
KIT
PD-L1
Infinity
HSP90
ARIAD
mTOR
QINLOCK
Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR2
TIE-2
Fms/CSF-1
BRAF
PDGFRB
Deciphera / Array
Bayer
FGFR1
FGFR2
FGFR3
FGFR4
Istodax
Gloucester Pharmaceuticals
HDAC
Array Biopharma/AstraZeneca
MEK 1/2
Rapamune
Wyeth
mTOR
Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR
Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF
Novartis
PKC theta
PKC alpha
PKC beta
Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET
Sutent + Stivarga
Pfizer + Bayer
Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)
Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)
Novartis
IGF-1R
FAK
Talzenna
Pfizer
PARP1
PARP2
Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)
Millenium
KIT
FLT3
PDGFRA
Calithera Biosciences, Inc
Glutaminase (GLS)
Calithera & Pfizer
Glutaminase (GLS)
PARP1
PARP2
Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB
Temodar
Schering-Plough
DNA methylation
Torisel
Wheth Pharmaceuticals
mTOR
Mundipharma-EDO Gmbh
Histone-deacetylase

255 drugs found

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