Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
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257 drugs found

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Targets
Zolinza
Merck
HDAC
Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB
ARIAD
mTOR
BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K
Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)
Zelboraf
Plexxicon
BRAF V600E
Oncothyreon
HIF-1α
OSI
IGF1R
IR (insulin receptor)
Caprelsa
AstraZeneca
EGFR
VEGFR
Novartis
PI3K
mTOR
Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)
Piramed
PI3K Class 1
Novartis
PI3K Class 1
AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB
Exelixis
PI3K Class I
Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor
Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2
Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)
Genentech
PI3K
MEK
Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB
Velcade
Millennium
26S proteasome
Tasigna + Gleevec
Novartis
OSI
KIT
VEGFR
ImClone
PDGFRA
Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)
Torisel
Wheth Pharmaceuticals
mTOR
Novartis
Astex Therapeutics, Ltd.
HSP90
Incyte
IDO1
Novartis
HSP90
Genentech
IDO1
Novartis/Vernalis
Hsp90
Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)
TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K
Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl
ImClone
IGF-1R
Amgen
VEGFR1
VEGFR2
VEGFR3
KIT
Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)
Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells
Schering-Plough
IGF1R
Amgen
IGF1R
MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)
ChemGenex Pharmaceuticals
80S ribosome
Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)
Novartis
PKC theta
PKC alpha
PKC beta
Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR
Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK
HDAC (vorinostat)
26S proteasome (bortezomib)
PDK
PDKII
Infinity
HSP90
Millenium
KIT
FLT3
PDGFRA
Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3
Erivedge
Genentech
SMO (smoothened receptor)
Array Biopharma/AstraZeneca
MEK 1/2
Oncothyreon
PI3K Class I
Avastin
Genentech Bio-oncology
VEGF-A
Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)
Genentech/Exelixis
MEK
Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)
Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)
Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB
Exelixis
KIT
VEGFR2
PDGFRB
Bristol-Myers Squibb
VEGFR2
FGFR
MEK 1/2
mTOR (CCI-779)
Novartis
IGF-1R
FAK
Kirin
IGF-1R
EntreMed
Aurora Kinase A
Aurora Kinase B
VEGFR2
KIT
FGFR1
Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)
Serenex
HSP90
None, Adriamycin
Aventis,
ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)
Exelixis
IGF1R
Scr
FGFR
Bcr-Abl
Aventis
Istodax
Gloucester Pharmaceuticals
HDAC
Amgen
IGF-1R (AMG 479)
DR5 (Death receptor 5) (AMG 655)
Hoffman-La Roche
gama-secretase
Gemzar, Taxotere
Topo/Target A/S
Keryx
AKT
Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)
Gleevec, Sutent
Daiichi Sankyo
DR5 (TRAIL-R2) (CS-1008)
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-abl
VEGFRs (sunitinib)
FLT3 (sunitinib)
CSF-1R (sunitinib)
RET (sunitinib)
GSK
IGF1R
Temodar
Schering-Plough
DNA methylation
Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF
Merck
IGF1R
Biogen Idec
HSP90
Sandostatin
Novartis
SSTR
Bristol-Myers Squibb
IGF-1R
Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)
Yondelis
Johnson & Johnson
Insmed
IGF1R
Novartis
IGF1R
Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump
Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)
Bristol-Myers Squibb
IGF1R
Biogen Idec
IGF1R
Hoffmann-La Roche
IGF1R
Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl
Pfizer
IGF1R
Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)
Infinity
HSP90
Biogen Idec
HSP90
Roche
MDM2
Novartis
PI3K Class 1A
Novartis
MEK 1/2
Novartis
PI3K Class 1A
MEK 1/2
Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2
Novartis
PI3K Class 1
MEK 1/2
Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)
Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A
Mekinist
GlaxoSmithKline
MEK1
MEK2
GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)
Pfizer

257 drugs found

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