Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

234 drugs found

Targets

OSI
KIT
VEGFR

ImClone
PDGFRA

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Torisel
Wheth Pharmaceuticals
mTOR

Novartis

Astex Therapeutics, Ltd.
HSP90

Incyte
IDO1

Novartis
HSP90

Genentech
IDO1

Novartis/Vernalis
Hsp90

Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)

TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl

ImClone
IGF-1R

Amgen
VEGFR1
VEGFR2
VEGFR3
KIT

Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)

Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells

Schering-Plough
IGF1R


Amgen
IGF1R

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)

ChemGenex Pharmaceuticals
80S ribosome

Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)

Novartis
PKC theta
PKC alpha
PKC beta

Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR

Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK

HDAC (vorinostat)
26S proteasome (bortezomib)

PDK
PDKII

Infinity
HSP90


Millenium
KIT
FLT3
PDGFRA

Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3

Erivedge
Genentech
SMO (smoothened receptor)

Array Biopharma/AstraZeneca
MEK 1/2

Oncothyreon
PI3K Class I

Avastin
Genentech Bio-oncology
VEGF-A

Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)

Genentech/Exelixis
MEK

Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)

Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)

Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB

Exelixis
KIT
VEGFR2
PDGFRB

Bristol-Myers Squibb
VEGFR2
FGFR

MEK 1/2
mTOR (CCI-779)

Novartis
IGF-1R
FAK

Kirin
IGF-1R

EntreMed
Aurora Kinase A
Aurora Kinase B
VEGFR2
KIT
FGFR1

Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)

Serenex
HSP90

None, Adriamycin
Aventis,

ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)

Exelixis
IGF1R
Scr
FGFR
Bcr-Abl


Aventis

Istodax
Gloucester Pharmaceuticals
HDAC

Amgen
IGF-1R (AMG 479)
DR5 (Death receptor 5) (AMG 655)

Hoffman-La Roche
gama-secretase

Gemzar, Taxotere

Topo/Target A/S

Keryx
AKT

Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)

Gleevec, Sutent
Daiichi Sankyo
DR5 (TRAIL-R2) (CS-1008)
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-abl
VEGFRs (sunitinib)
FLT3 (sunitinib)
CSF-1R (sunitinib)
RET (sunitinib)


GSK
IGF1R

Temodar
Schering-Plough
DNA methylation

Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF

Merck
IGF1R

Biogen Idec
HSP90

Sandostatin
Novartis
SSTR

Bristol-Myers Squibb
IGF-1R

Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)


Yondelis
Johnson & Johnson

Insmed
IGF1R

Novartis
IGF1R

Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump

Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)

Bristol-Myers Squibb
IGF1R

Biogen Idec
IGF1R

Hoffmann-La Roche
IGF1R

Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl

Pfizer
IGF1R

Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)

Infinity
HSP90


Biogen Idec
HSP90

Roche
MDM2

Novartis
PI3K Class 1A

Novartis
MEK 1/2

Novartis
PI3K Class 1A
MEK 1/2

Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2

Novartis
PI3K Class 1
MEK 1/2

Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)

Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A

Mekinist
GlaxoSmithKline
MEK1
MEK2

GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)

Pfizer

Pfizer

Campostar
Pfizer

Pfizer

EMD Serono

EMD Serono

EMD Serono

Genentech

Genentech

Bayer
PI3K

Bayer
MEK

Bayer
PI3K
MEK


Novartis


Novartis
FGFR
FGFR1
FGFR2
FGFR3

BerGenBio
AXL

Novartis
KIT (imatinib)
FGFR

234 drugs found