Drug Detail

Information about Sprycel + Avastin

Generic Name	Dasatinib + Bevacizumab
IND	Dasatinib + Bevacizumab
Brand Name (US)	Sprycel + Avastin
Manufacturer	Bristol Myers-Squibb + Genetech
Drug Type	Tyrosine Kinase Inhibitor and Monoclonal antibody
Delivery	Oral + Intravenous
Approval Status	Both are approved. This combination is not approved for GIST. It was evaluated in a phase 1 trial for non-GIST cancers.
Indications
Overall Strategy	GIST cell based
Strategy	Block KIT + Block blood vessel growth
Drug Category	KIT/PDGFRA inhibitor+ VEGF inhibitor (antibody)

BCR-ABL, SRC family (SRC, LCK, YES, FYN), KIT, EPHA2, and PDGFRβ