Drug Detail

Information about AMG 479 + AMG 655

Generic Name
IND	AMG 479 + AMG 655
Brand Name (US)
Manufacturer	Amgen
Drug Type	monoclonal antibody
Delivery	Intravenous
Approval Status	Phase 1
Indications
Overall Strategy	Oncogenic Signal Path Based
Strategy	Block related tumor signal paths
Drug Category	IGF1R inhibitor + DR5 Inhibitor

AMG 479 is a fully human monoclonal antibody against the insulin-like growth factor receptor (IGF-1R). It inhibits IGF-1R signaling by binding to the IGF-1R receptor and blocking growth factor activation of the receptor.
AMG 655 is a fully human monoclonal antibody agonist that targets death receptor 5 (“DR5”) and induces apoptosis in sensitive tumor cells. It is being investigated as a cancer treatment.