Drug Detail

Information about AZD6244 plus Temsirolimus

Generic Name
IND	AZD6244 plus Temsirolimus
Brand Name (US)
Manufacturer
Drug Type
Delivery
Approval Status	Phase2
Indications
Overall Strategy
Strategy
Drug Category	mTOR inhibitor + MEK inhibitor

RATIONALE: MEK inhibitor AZD6244 and temsirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not yet known whether giving MEK inhibitor AZD6244 together with temsirolimus is more effective than giving MEK inhibitor AZD6244 alone. Neither of these drugs are in GIST-specific trials.

PURPOSE: A randomized phase II trial is studying how well giving MEK inhibitor AZD6244 together with or without temsirolimus works in treating patients with metastatic, recurrent, or locally advanced soft tissue sarcoma that cannot be removed by surgery