Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

249 drugs found

Targets

Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)

Zolinza
Merck
HDAC

Erivedge
Genentech
SMO (smoothened receptor)

Venclexta
Abbvie / Genetech
BCL-2

Zelboraf
Plexxicon
BRAF V600E

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB

Caprelsa
AstraZeneca
EGFR
VEGFR

AstraZeneca
CTLA-4

GlaxoSmithKline

Mekinist
GlaxoSmithKline
MEK1
MEK2

Yondelis
Johnson & Johnson

AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB

Mundipharma-EDO Gmbh
Histone-deacetylase


Edo

Torisel
Wheth Pharmaceuticals
mTOR

Temodar
Schering-Plough
DNA methylation

Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB

Calithera & Pfizer
Glutaminase (GLS)
PARP1
PARP2

Calithera Biosciences, Inc
Glutaminase (GLS)

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Millenium
KIT
FLT3
PDGFRA

Talzenna
Pfizer
PARP1
PARP2

Novartis
IGF-1R
FAK


Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)

Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)

Sutent + Stivarga
Pfizer + Bayer

Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET

Novartis
PKC theta
PKC alpha
PKC beta

Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF

Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR

Rapamune
Wyeth
mTOR

Array Biopharma/AstraZeneca
MEK 1/2

Istodax
Gloucester Pharmaceuticals
HDAC

Bayer
FGFR1
FGFR2
FGFR3
FGFR4

Deciphera / Array

QINLOCK
Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR2
TIE-2
Fms/CSF-1
BRAF
PDGFRB

ARIAD
mTOR

Infinity
HSP90

Bayer, Merck
KIT
PD-L1

Stivarga
Bayer
MEK

Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl

Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2

Cogent Biosciences
KIT
FLT3
CSF-1R

Plexxicon + Merck


PharmaMar
Tubulin

Taiho Phrmaceutical Co.

EMD Serono

Piramed
PI3K Class 1

Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R

Keryx
AKT

Merck + Incyte
PD-1
IDO1

Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg

Keytruda
Merck
PD-1

Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)

GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)

Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)

Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3

Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)

Farydak
Novartis
HDAC

Ibrance
Pfizer
Cdk4
Cdk6

Taxol
Pfizer
Tubulin

Astex Therapeutics, Ltd.
HSP90

ChemGenex Pharmaceuticals
80S ribosome

Ascentage Pharma
Bcr-Abl
KIT

Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump

ImClone
PDGFRA

Sandostatin
Novartis
SSTR

Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4

Bristol-Myers Squibb

Opdivo
Bristol-Myers Squibb
PD-1

Tasigna + Gleevec
Novartis

Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK

Advanced Accelerator Aplications
GRPR

BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR

Abbott
BCL-2

Amgen
VEGFR1
VEGFR2
VEGFR3
KIT

Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells

Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR

AB Science
KIT
PDGFR
FGFR3
Lyn

OSI
IGF1R
IR (insulin receptor)

Lenvima
Eisai Co.
KIT
PDGFRa
VEGFR1
VEGFR2
VEGFR3
RET
FGFR1
FGFR2
FGFR3
FGFR4

Loxo Oncology
TrkA
TrkB
TrkC
NTRK

Campostar
Pfizer

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)

Yervoy
Bristol-Myers Squibb
CTLA-4

Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB

Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)

KIT
PDGFRa
XPO1

Glivec + Stivarga
Novartis + Bayer

Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl

Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl

Novartis
KIT
PD-1

Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl

Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)

Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3


Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)

Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR

Gleevec + Dovitinib
Novartis

Novartis

Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)

KIT
PDGFRa
PD-L1

Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)

Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)

Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB

Intuvax
Immunicum
CD8 and CD4 positive T-cells


Astex Pharmaceuticals

Gemzar, Taxotere

Synta
HSP90

Aventis

None, Adriamycin
Aventis,

Pfizer
IGF1R

cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3

Afinitor/Certican
Novartis
mTOR

Incyte

Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK

249 drugs found