Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

242 drugs found

Targets

Piramed
PI3K Class 1

Genentech
PI3K
MEK

Genentech/Exelixis
MEK

Genentech

Genentech/Piramed Ltd.
PI3K
mTOR

GSK
IGF1R

Mekinist
GlaxoSmithKline
MEK1
MEK2

TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3


Aventis

Ascentage Pharma
Bcr-Abl
KIT

Novartis/Vernalis
Hsp90

Stanford University
CD47


IDRx, Inc.
KIT V654A
PDGFRa V651D

Novartis
KIT (imatinib)
FGFR

Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)

Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl

Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3

Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)

ImClone
PDGFRA

ImClone
IGF-1R

ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)

Inhibrx, Inc.
DR5 (Death receptor 5)

Inhibrx, Inc.
DR5 (Death receptor 5)
DR5 (Death receptor 5)

Incyte

Incyte
IDO1

Insmed
IGF1R

Infinity
HSP90

Infinity
HSP90

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)

ISA Pharmaceuticals

Keryx
AKT

Kolltan
Kit

Kirin
IGF-1R

Novartis

Farydak
Novartis
HDAC

Novartis

Novartis
KIT

Loxo Oncology
TrkA
TrkB
TrkC
NTRK

Yervoy
Bristol-Myers Squibb
CTLA-4

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)

Medimmune
PD-L1
B7H1

Novartis
MEK 1/2

Novartis
PI3K Class 1A
MEK 1/2

Merck
IGF1R

Keytruda
Merck
PD-1

Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg

Zolinza
Merck
HDAC

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Millenium
KIT
FLT3
PDGFRA

Hoffman-La Roche
PD-L1

EMD Serono

EMD Serono

Ningbo Newbay
KIT
PDGFRA

Genentech
IDO1

Novartis
IGF1R

Sandostatin
Novartis
SSTR

OSI
IGF1R
IR (insulin receptor)

OSI
KIT
VEGFR

Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump

Pfizer

Ibrance
Pfizer
Cdk4
Cdk6

Novartis
PD-1

Campostar
Pfizer

Pfizer

Pfizer

Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR

Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R

Zelboraf
Plexxicon
BRAF V600E

Cogent Biosciences
KIT
FLT3
CSF-1R

PharmaMar
Tubulin


Velcade
Millennium
26S proteasome

Peloton
HIF-2a

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB

Oncothyreon
HIF-1α

Oncothyreon
PI3K Class I

Topo/Target A/S

Hoffmann-La Roche
IGF1R

Afinitor/Certican
Novartis
mTOR

Roche
MDM2

Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)

Hoffman-La Roche
gama-secretase

Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK

EMD Serono

Schering-Plough
IGF1R

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Astex Pharmaceuticals

cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3

Rapamune
Wyeth
mTOR

Serenex
HSP90

Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)

Synta
HSP90

Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)

Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)

Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB

Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)

Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)

Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl

Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl

Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR

Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)

Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET

Sutent + Stivarga
Pfizer + Bayer

Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)

Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)

Novartis
IGF-1R
FAK

Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta

Theseus
KIT
PDGFRa

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)

HDAC (vorinostat)
26S proteasome (bortezomib)

Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

Exelixis
IGF1R
Scr
FGFR
Bcr-Abl

Exelixis
PI3K Class I

Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK

Exelixis
KIT
VEGFR2
PDGFRB

242 drugs found