Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
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249 drugs found

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Targets
Medimmune
PD-L1
B7H1
Stanford University
CD47
Kolltan
Kit
Tumor antigens
ArQule
AKT
Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK
Loxo Oncology
TrkA
TrkB
TrkC
NTRK
Abbott
BCL-2
BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR
BerGenBio
AXL
Advanced Accelerator Aplications
GRPR
Astex Pharmaceuticals
MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R
AstraZeneca
CTLA-4
PD-L1
CTLA-4
Merck + Incyte
PD-1
IDO1
Incyte
Mundipharma-EDO Gmbh
Histone-deacetylase
Xencor
SSTR2
CD3
PharmaMar
Tubulin
Edo
Peloton
HIF-2a
Calithera & Pfizer
Glutaminase (GLS)
PARP1
PARP2
Amgen
KRAS G12C
Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta
CStone Pharmaceuticals
PD-L1
CStone Pharmaceuticals
PDL-1
KIT
PDGFRa
Pfizer
PD-L1
KIT
KIT
PDGFRa
XPO1
Advenchen Laboratories
KIT
PDGFRa
VEGFR2
VEGFR3
Novartis
KIT
PD-1
Ascentage Pharma
Bcr-Abl
KIT
Bayer, Merck
KIT
PD-L1
Daichi Sanyo
TOPO-1
GPR20
Bayer
FGFR1
FGFR2
FGFR3
FGFR4
Ningbo Newbay
KIT
PDGFRA
cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3
Deciphera / Array
Theseus
KIT
PDGFRa
Cogent Bioscience
KIT
Cogent Biosciences
KIT Exon 17
IDRx, Inc.
KIT V654A
PDGFRa V651D
Advanced Accelerator Applications
Inhibrx, Inc.
DR5 (Death receptor 5)
Inhibrx, Inc.
DR5 (Death receptor 5)
DR5 (Death receptor 5)
Taiho Phrmaceutical Co.
KIT
PDGFRa
PD-L1
HIF2A
Deciphera
ULK1/2
Deciphera
ULK1/2
KIT
Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl
Afinitor/Certican
Novartis
mTOR
Avastin
Genentech Bio-oncology
VEGF-A
AYVAKIT
Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V
Ayvakit
Blueprint Medicines Corporation
PDGFRA (D842V)
KIT exon 17
KIT D816V
BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K
Campostar
Pfizer
Caprelsa
AstraZeneca
EGFR
VEGFR
Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2
Erivedge
Genentech
SMO (smoothened receptor)
Farydak
Novartis
HDAC
Gemzar, Taxotere
Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB
Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl
Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3
Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl
Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR
Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)
Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)
Gleevec + Dovitinib
Novartis
Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)
Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl
Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)
Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)
Gleevec, Sutent
Daiichi Sankyo
DR5 (TRAIL-R2) (CS-1008)
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-abl
VEGFRs (sunitinib)
FLT3 (sunitinib)
CSF-1R (sunitinib)
RET (sunitinib)
Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB
Glivec + Stivarga
Novartis + Bayer
Ibrance
Pfizer
Cdk4
Cdk6
Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2
Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)
Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1
Intuvax
Immunicum
CD8 and CD4 positive T-cells
Istodax
Gloucester Pharmaceuticals
HDAC
Keytruda
Merck
PD-1
Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg
Lenvima
Eisai Co.
KIT
PDGFRa
VEGFR1
VEGFR2
VEGFR3
RET
FGFR1
FGFR2
FGFR3
FGFR4
Mekinist
GlaxoSmithKline
MEK1
MEK2
Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR
Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF
None, Adriamycin
Aventis,
Opdivo
Bristol-Myers Squibb
PD-1
Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4
QINLOCK
Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR2
TIE-2
Fms/CSF-1
BRAF
PDGFRB
Rapamune
Wyeth
mTOR
Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB
Rivoceranib
Jiangsu Hengrui Medicine
VEGFR2
Sandostatin
Novartis
SSTR
Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC
Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)
Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)
Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl
Stivarga
Bayer
MEK
Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET
Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)
Sutent + Stivarga
Pfizer + Bayer
Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)
TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K
Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2
Talzenna
Pfizer
PARP1
PARP2
Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK
Tasigna + Gleevec
Novartis
Taxol
Pfizer
Tubulin
Temodar
Schering-Plough
DNA methylation
Torisel
Wheth Pharmaceuticals
mTOR
Velcade
Millennium
26S proteasome
Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)

249 drugs found

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