Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

249 drugs found

Targets

Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)

Zolinza
Merck
HDAC

Zelboraf
Plexxicon
BRAF V600E

Yondelis
Johnson & Johnson

Yervoy
Bristol-Myers Squibb
CTLA-4

Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)

Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)

Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3

Venclexta
Abbvie / Genetech
BCL-2

Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)

Velcade
Millennium
26S proteasome

Torisel
Wheth Pharmaceuticals
mTOR

Temodar
Schering-Plough
DNA methylation

Taxol
Pfizer
Tubulin

Tasigna + Gleevec
Novartis

Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK

Talzenna
Pfizer
PARP1
PARP2

Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2

TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K

Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)

Sutent + Stivarga
Pfizer + Bayer

Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET

Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)

Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl

Stivarga
Bayer
MEK

Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)

Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)

Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC

Sandostatin
Novartis
SSTR

Rivoceranib
Jiangsu Hengrui Medicine
VEGFR2

Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB

Rapamune
Wyeth
mTOR

QINLOCK
Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR2
TIE-2
Fms/CSF-1
BRAF
PDGFRB

Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4

Opdivo
Bristol-Myers Squibb
PD-1

None, Adriamycin
Aventis,

Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF

Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR

Mekinist
GlaxoSmithKline
MEK1
MEK2

Lenvima
Eisai Co.
KIT
PDGFRa
VEGFR1
VEGFR2
VEGFR3
RET
FGFR1
FGFR2
FGFR3
FGFR4

Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg

Keytruda
Merck
PD-1

Istodax
Gloucester Pharmaceuticals
HDAC

Intuvax
Immunicum
CD8 and CD4 positive T-cells

Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1

Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)

Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2

Ibrance
Pfizer
Cdk4
Cdk6

Glivec + Stivarga
Novartis + Bayer

Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB

Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)

Gleevec, Sutent
Daiichi Sankyo
DR5 (TRAIL-R2) (CS-1008)
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-abl
VEGFRs (sunitinib)
FLT3 (sunitinib)
CSF-1R (sunitinib)
RET (sunitinib)

Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)

Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl

Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)

Gleevec + Dovitinib
Novartis

Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)

Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)

Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR

Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB

Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl

Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3

Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl

Gemzar, Taxotere

Farydak
Novartis
HDAC

Erivedge
Genentech
SMO (smoothened receptor)

Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2

Caprelsa
AstraZeneca
EGFR
VEGFR

Campostar
Pfizer

BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K

AYVAKIT
Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V

Ayvakit
Blueprint Medicines Corporation
PDGFRA (D842V)
KIT exon 17
KIT D816V

Avastin
Genentech Bio-oncology
VEGF-A

Afinitor/Certican
Novartis
mTOR

Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl

OSI
KIT
VEGFR

Exelixis
KIT
VEGFR2
PDGFRB

Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor

Infinity
HSP90

AB Science
KIT
PDGFR
FGFR3
Lyn

Novartis
HSP90

Novartis
PI3K
mTOR

Biogen Idec
HSP90

Amgen
VEGFR1
VEGFR2
VEGFR3
KIT

Aventis

Bristol-Myers Squibb
VEGFR2
FGFR

Synta
HSP90

Oncothyreon
HIF-1α

Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)

Oncothyreon
PI3K Class I

Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)

Piramed
PI3K Class 1

Serenex
HSP90

Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK

Infinity
HSP90

Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)

PDK
PDKII

Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR

Novartis
IGF-1R
FAK

Exelixis
PI3K Class I

Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2

Hoffmann-La Roche
IGF1R

Novartis
PKC theta
PKC alpha
PKC beta

Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells

Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB


Keryx
AKT

Astex Therapeutics, Ltd.
HSP90


Novartis
PI3K Class 1

Novartis/Vernalis
Hsp90

Topo/Target A/S

Novartis
IGF1R

Bristol-Myers Squibb
IGF1R

Insmed
IGF1R

Exelixis
IGF1R
Scr
FGFR
Bcr-Abl

OSI
IGF1R
IR (insulin receptor)

GSK
IGF1R

Pfizer
IGF1R

ImClone
IGF-1R

249 drugs found