Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

255 drugs found

Targets

ImClone
IGF-1R

Schering-Plough
IGF1R

Merck
IGF1R

Amgen
IGF1R

ChemGenex Pharmaceuticals
80S ribosome

Biogen Idec
IGF1R

Kirin
IGF-1R

MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)


ARIAD
mTOR

Bristol-Myers Squibb
IGF-1R

Amgen
IGF-1R (AMG 479)
DR5 (Death receptor 5) (AMG 655)

ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)

HDAC (vorinostat)
26S proteasome (bortezomib)

Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB

Biogen Idec
HSP90

Millenium
KIT
FLT3
PDGFRA

Genentech/Piramed Ltd.
PI3K
mTOR

Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R

Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump

Genentech/Exelixis
MEK

Genentech
PI3K
MEK

EntreMed
Aurora Kinase A
Aurora Kinase B
VEGFR2
KIT
FGFR1

Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3

AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB

Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R

Array Biopharma/AstraZeneca
MEK 1/2

MEK 1/2
mTOR (CCI-779)

ImClone
PDGFRA


Roche
MDM2

Novartis
PI3K Class 1A

Novartis
MEK 1/2

Novartis
PI3K Class 1A
MEK 1/2

Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2

Novartis
PI3K Class 1
MEK 1/2

Hoffman-La Roche
gama-secretase

Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)


Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)

Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A

GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)

Pfizer

Pfizer

Pfizer

EMD Serono

EMD Serono

EMD Serono

Genentech

Genentech

Bayer
PI3K

Bayer
MEK

Bayer
PI3K
MEK

Novartis



Novartis

Bristol-Myers Squibb
LAG-3

Bristol-Myers Squibb

GlaxoSmithKline

Incyte
IDO1

Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)

Novartis
FGFR
FGFR1
FGFR2
FGFR3
VEGFR2

Novartis
KIT (imatinib)
FGFR

Calithera Biosciences, Inc
Glutaminase (GLS)

Boston Biomedical
NANOG

Novartis
KIT

Genentech
IDO1

Cogent Biosciences
KIT

Cogent Biosciences
KIT
FLT3
CSF-1R

Hoffman-La Roche
PD-L1

Hoffman-La Roche

Plexxicon + Merck

Novartis
PD-1

ISA Pharmaceuticals

Novartis

Medimmune
PD-L1
B7H1

Stanford University
CD47

Kolltan
Kit

Tumor antigens

ArQule
AKT

Ignyta
TrkA
TrkB
TrkC
ROS1
ALK
NTRK

Loxo Oncology
TrkA
TrkB
TrkC
NTRK

Abbott
BCL-2

BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR

BerGenBio
AXL

Advanced Accelerator Aplications
GRPR

Astex Pharmaceuticals

MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R

AstraZeneca
CTLA-4

PD-L1
CTLA-4

Merck + Incyte
PD-1
IDO1

Incyte

Mundipharma-EDO Gmbh
Histone-deacetylase

Xencor
SSTR2
CD3

PharmaMar
Tubulin




Edo

Peloton
HIF-2a

Calithera & Pfizer
Glutaminase (GLS)
PARP1
PARP2

Amgen
KRAS G12C

Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta

CStone Pharmaceuticals
PD-L1

CStone Pharmaceuticals
PDL-1
KIT
PDGFRa

Pfizer
PD-L1
KIT

KIT
PDGFRa
XPO1

Advenchen Laboratories
KIT
PDGFRa
VEGFR2
VEGFR3

Novartis
KIT
PD-1

Ascentage Pharma
Bcr-Abl
KIT

Bayer, Merck
KIT
PD-L1

Daichi Sanyo
TOPO-1
GPR20

Bayer
FGFR1
FGFR2
FGFR3
FGFR4

Ningbo Newbay
KIT
PDGFRA

cKit
PDGFRa
VEGFR2
VEGFR3
FLT1
FLT3

Deciphera / Array

Theseus
KIT
PDGFRa

Cogent Bioscience
KIT

Cogent Biosciences
KIT Exon 17

255 drugs found