Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

259 drugs found

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Targets
Kura Oncology Inc
Menie-MLL
KIT
PDGFRA
Menin-MLL
Zolinza + Nexavar
Merck + Bayer
KIT
PDGFRA
PDGFRB
BRAF
Mutant BRAF
CRAF
VEGFR
HDAC (vorinostat)
Zolinza
Merck
HDAC
Erivedge
Genentech
SMO (smoothened receptor)
Venclexta
Abbvie / Genetech
BCL-2
Zelboraf
Plexxicon
BRAF V600E
Novartis
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRB
Caprelsa
AstraZeneca
EGFR
VEGFR
AstraZeneca
CTLA-4
GlaxoSmithKline
Mekinist
GlaxoSmithKline
MEK1
MEK2
Yondelis
Johnson & Johnson
AVEO Pharmaceuticals, Inc.
VEGFR-1, 2, 3
KIT
PDGFRB
Mundipharma-EDO Gmbh
Histone-deacetylase
Edo
Torisel
Wheth Pharmaceuticals
mTOR
Temodar
Schering-Plough
DNA methylation
Bayer/ACT BIOTECH
KIT
VEGFR2
VEGFR3
PDGFRB
Calithera & Pfizer
Glutaminase (GLS)
PARP1
PARP2
Calithera Biosciences, Inc
Glutaminase (GLS)
Millennium
KIT
FLT3
PDGFRB
PDGFRA (possible)
Millenium
KIT
FLT3
PDGFRA
Talzenna
Pfizer
PARP1
PARP2
Novartis
IGF-1R
FAK
Sutent
Pfizer, Pfizer
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
IGF1R (CP-751,871)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
SCF-1R (sunitinib)
RET (sunitinib)
Sutent + TH-302
Pfizer, Threshold Pharmaceuticals
KIT (sunitinib)
PDGFRA (sunitinib)
VEGFRs (sunitinib)
Hypoxia (TH-302)
Sutent + Stivarga
Pfizer + Bayer
Sutent
Pfizer
KIT
PDGFRA
PDGFRB
VEGFR1
VEGFR2
VEGFR3
FLT3
CSF-1R
RET
Novartis
PKC theta
PKC alpha
PKC beta
Nexavar + Avastin
Bayer and Genentech
KIT (Sorafenib)
PDGFR (Sorafenib)
VEGFR (Sorafenib)
VEGFR (Bevacizumab)
BRAF (Sorafenib)
mutant BRAF (Sorafenib)
CRAF
Nexavar
Bayer
KIT
Raf-1
PDGFRB
BRAF
Mutant BRAF
FLT3
VEGFR
Rapamune
Wyeth
mTOR
Array Biopharma/AstraZeneca
MEK 1/2
Istodax
Gloucester Pharmaceuticals
HDAC
Bayer
FGFR1
FGFR2
FGFR3
FGFR4
Deciphera / Array
QINLOCK
Deciphera Pharmaceuticals, LLC
KIT
PDGFRA
VEGFR2
TIE-2
Fms/CSF-1
BRAF
PDGFRB
ARIAD
mTOR
Infinity
HSP90
Bayer, Merck
KIT
PD-L1
Stivarga
Bayer
MEK
Stivarga
Bayer
Raf-1
BRAF
VEGRF2
VEGFR3
KIT
PDGFRA
PDGFRB
RET
TIE-2
DDR-2
FGFR1
FGFR2
Trk2A
Eph2A
BRAF V600E
SAPK2
PTK5
Abl
Iclusig
ARIAD
Bcr-Abl
KIT
PDGFRA
VEGFR
FLT3
FGFR
EPH
SRC family
RET
TIE-2
Cogent Biosciences
KIT
FLT3
CSF-1R
Plexxicon + Merck
PharmaMar
Tubulin
Taiho Phrmaceutical Co.
EMD Serono
Piramed
PI3K Class 1
Plexxicon
KIT
FLT3
Fms/CSF-1
CSF-1R
Keryx
AKT
Merck + Incyte
PD-1
IDO1
Keytruda + Cyclophosphamide
PD-1
CD4+ Treg
CD8+ Treg
Keytruda
Merck
PD-1
Votrient + Zolinza
GlaxoSmithKline & Merck
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
HDAC (vorinostat)
GlaxoSmithKline
KIT (pazopanib)
MEK (Trametinib)
VEGFRS (pazopanib)
PDGFRA (pazopanib)
Votrient + Hycamtin
GlaxoSmithKline
KIT (pazopanib)
PDGFRA (pazopanib)
PDGFRB (pazopanib)
VEGFRS (pazopanib)
Topoisomerase I (topetecan)
Votrient
GlaxoSmithKline
KIT
VEGFR-1, 2, 3
PDGFRA
PDGFRB
Itk
LCK
c-Fms
FGFR -1 and -3
Novartis
SST-1
SST-2
SST-3
SST-5
Somatostatin receptors (SST-1, SST-2, SST-3, SST-5)
Farydak
Novartis
HDAC
Ibrance
Pfizer
Cdk4
Cdk6
Taxol
Pfizer
Tubulin
Astex Therapeutics, Ltd.
HSP90
ChemGenex Pharmaceuticals
80S ribosome
Ascentage Pharma
Bcr-Abl
KIT
Phoenix Biotechnology, Inc.
α-3 subunit of Na-K ATPase pump
ImClone
PDGFRA
Sandostatin
Novartis
SSTR
Opdivo + Yervoy
Bristol-Myers Squibb
PD-1
CTLA-4
Bristol-Myers Squibb
Opdivo
Bristol-Myers Squibb
PD-1
Tasigna + Gleevec
Novartis
Tasigna
Novartis
DDR-1
DDR-2
Bcr-Abl
PDGFRA
PDGFRB
KIT
MAPK11
MAPK12
ZAK
Advanced Accelerator Aplications
GRPR
BCL-2
KIT
Raf-1
PDGFRB
BRAF
mutant BRAF
FLT3
VEGFR
Abbott
BCL-2
Amgen
VEGFR1
VEGFR2
VEGFR3
KIT
Cobra Biomanufacturing Plc
CD8 and CD4 positive T-cells
Novartis
PKC alpha
KIT
PDGFRA
PDGFRA (D842V)
VEGFR1
VEGFR2
VEGFR3
FLT3
PKC beta
PKC gamma
FGFR
AB Science
KIT
PDGFR
FGFR3
Lyn
Liporaxel
Dae Hwa Pharmaceutical
Tubulin
OSI
IGF1R
IR (insulin receptor)
Lenvima
Eisai Co.
KIT
PDGFRa
VEGFR1
VEGFR2
VEGFR3
RET
FGFR1
FGFR2
FGFR3
FGFR4
Loxo Oncology
TrkA
TrkB
TrkC
NTRK
Campostar
Pfizer
Sprycel + Yervoy
Bristol-Myers Squibb (both)
CTLA-4 (ipilimumab)
KIT (dasatinib)
PDGFRB (dasatinib)
bcr-abl (dasatinib)
SCR (dasatinib)
EPHA2 (dasatinib)
LCK (dasatinib)
YES (dasatinib)
FYN (dasatinib)
Yervoy
Bristol-Myers Squibb
CTLA-4
Novartis
FGFR
FGFR1
FGFR2
FFGFR3
KIT
PDGFRA
VEGFR2
Novartis
FGFR
FGFR1
FGFR2
FGFR3
VEGFR2
Gleevec, Tasigna
Novartis + Novartis
Both have similar targets
KIT
Bcr-abl
PDGFRA
PDGFRB
Gleevec, Sutent
Novartis, Pfizer
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-Abl (imatinib)
VEGFR1 (sunitinib)
VEGFR2 (sunitinib)
VEGFR3 (sunitinib)
FLT3 (sunitinib)
CSR-1R (sunitinib)
RET (sunitinib)
KIT
PDGFRa
XPO1
Glivec + Stivarga
Novartis + Bayer
Gleevec
Novartis + Keryx
KIT
AKT
PDGFRA
Bcr-Abl
Gleevec + PEG-Intron
Novartis, Schering
KIT
PDGFRA
Bcr-Abl
Novartis
KIT
PD-1
Gleevec
Novartis + Novartis
HDAC
KIT
PDGFRA
PDGFRB
Bcr-Abl
Gleevec + Genasense
Novartis + Genta
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (imatinib)
Bcl-2 (Genasense)
Gleevec
Novartis
KIT
Bcr-Abl
PDGFRA
PKC alpha
PKC beta
PKC gamma
VEGFR
FGFR
FLT3
Novartis + Bristol Myers-Squibb
CTLA-4 (ipilimumab)
KIT (imatinib)
Gleevec + Afinitor
Novartis, Novartis
KIT
PDGFRA
Bcr-Abl
mTOR
Gleevec + Dovitinib
Novartis
Novartis
Gleevec + Avastin
Novartis and Genentech
KIT (imatinib)
VEGFR (bevacizumab)
PDGFRA (imatinib)
PDGFRB (imatinib)
Bcr-Abl (imatinib)
KIT
PDGFRa
PD-L1
Gleevec + AT13387
Astex Therapeutics
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
Hsp90 (AT13387)
Gleevec + Proleukin
Novartis + Novartis
KIT (Gleevec)
Bcr-Abl (imatinib)
PDGFRA (Gleevec)
Interleukin-2 (IL-2)
Gleevec
Novartis
KIT
bcr-abl
abl
PDGFRA
PDGFRB
Intuvax
Immunicum
CD8 and CD4 positive T-cells
Astex Pharmaceuticals
Gemzar, Taxotere
Synta
HSP90
Aventis

259 drugs found

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