Drug Watch List

Note: Some of these drugs are not in trials yet or are not in trials that we are monitoring for GIST.
Note: Click on a column title to sort the list  

249 drugs found

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Targets
BRAFTOVI
Array Biopharma
BRAF V600E
BRAF V600K
PD-L1
CTLA-4
Medimmune
PD-L1
B7H1
Adriamycin + Gleevec
Pharmacia & Upjohn + Novartis
KIT
PDGFRA
Bcr-Abl
Novartis
KIT
PDGFR
VEGFR1
VEGFR2
VEGFR3
FGFR1
FGFR2
FGFR3
FLT3
RET
TrkA
CSF-1R
PDK
PDKII
Tumor antigens
Deciphera
ULK1/2
KIT
Sprycel + Avastin
Bristol Myers-Squibb + Genetech
KIT
BCR-ABL
PDGFRB
SRC family
EPHA2
VEGFA (Bevacizumab)
Sprycel
Bristol-Myers Squibb
KIT
bcr-abl
SRC family
PDGFRB
EPHA2
LCK
YES
FYN
SRC
TAFINLAR
GlaxoSmithKline
BRAF
BRAF V600E
BRAF V600K
Tafinlar + Mekinist
GlaxoSmithKline
BRAF V600E
BRAF V600K
MEK 1/2
Gleevec, Sutent
Daiichi Sankyo
DR5 (TRAIL-R2) (CS-1008)
KIT (imatinib & sunitinib)
PDGFRA (imatinib & sunitinib)
Bcr-abl
VEGFRs (sunitinib)
FLT3 (sunitinib)
CSF-1R (sunitinib)
RET (sunitinib)
Arog Pharmaceuticals
PDGFRA
PDGFRB
PDGFRA (D842V)
FLT3
Hoffman-La Roche
Genentech/Exelixis
MEK
Biogen Idec
HSP90
ImClone
IGF-1R (IMC-A12)
mTOR (CCI-779)
ImClone
IGF-1R
Recentin
AstraZeneca
VEGFR1
VEGFR2
VEGFR3
KIT
PDGFRA
PDGFRB
Cometriq
Exelixis
c-MET
VEGFR-1, 2, 3
RET
KIT
FLT3
TEK
AXL
TRKB
TIE-2
Bristol-Myers Squibb
VEGFR2
FGFR
Velcade + Sutent
Millennium
KIT (sunitinib)
PDGFRA (sunitinib)
PDGFRB (sunitinib)
VEGFRs (sunitinib)
RET (sunitinib)
SCF-1R (sunitinib)
CSF-1R (sunitinib)
26S proteasome (bortezomib)
Velcade
Millennium
26S proteasome
MEK1/2
KIT
FLT3
Fms/CSF-1
CSF-1R
Novartis
MEK 1/2
Cogent Biosciences
KIT Exon 17
Cogent Bioscience
KIT
Avastin
Genentech Bio-oncology
VEGF-A
HIF2A
Topo/Target A/S
Inlyta + Keytruda
Pfizer + Merck
KIT
PDGFRa
VEGFR-1, 2, 3
T315I (BCR-ABL gatekeeper mutation)
PD-1
Inlyta
Pfizer
VEGFR-1, 2, 3
KIT
PDGFRA
T315I (BCR-ABL gatekeeper mutation)
Pfizer
PD-L1
KIT
Ayvakit
Blueprint Medicines Corporation
PDGFRA (D842V)
KIT exon 17
KIT D816V
AYVAKIT
Blueprint Medicines
PDGFRA (D842V)
KIT exon 17
KIT D816V
Hoffman-La Roche
PD-L1
Rivoceranib
Jiangsu Hengrui Medicine
VEGFR2
Advenchen Laboratories
KIT
PDGFRa
VEGFR2
VEGFR3
OSI
KIT
VEGFR
Exelixis
KIT
VEGFR2
PDGFRB
Novartis
PI3K Class I
mTOR Raptor
mTOR Rictor
Infinity
HSP90
Novartis
HSP90
Novartis
PI3K
mTOR
Oncothyreon
HIF-1α
Oncothyreon
PI3K Class I
Serenex
HSP90
Exelixis
PI3K Class I
mTOR Raptor
mTOR Rictor
DNA-PK
Genentech/Amgen
DR4 (Death receptor 4)
DR5 (Death receptor 5)
Exelixis
PI3K Class I
Semafore
PI3K Class 1A
DNA-PK
mTOR
Polo-like 1 kinases
PIM1
CK2
Hoffmann-La Roche
IGF1R
Novartis
PI3K Class 1
Novartis/Vernalis
Hsp90
Novartis
IGF1R
Bristol-Myers Squibb
IGF1R
Insmed
IGF1R
Exelixis
IGF1R
Scr
FGFR
Bcr-Abl
GSK
IGF1R
Schering-Plough
IGF1R
Merck
IGF1R
Amgen
IGF1R
Biogen Idec
IGF1R
Kirin
IGF-1R
MedImmune LLC
IGF1
IGF2
IGF-1R (indirectly)
IR-A (indirectly)
Bristol-Myers Squibb
IGF-1R
Amgen
IGF-1R (AMG 479)
DR5 (Death receptor 5) (AMG 655)
HDAC (vorinostat)
26S proteasome (bortezomib)
Biogen Idec
HSP90
Genentech/Piramed Ltd.
PI3K
mTOR
Genentech
PI3K
MEK
EntreMed
Aurora Kinase A
Aurora Kinase B
VEGFR2
KIT
FGFR1
MEK 1/2
mTOR (CCI-779)
Roche
MDM2
Novartis
PI3K Class 1A
Novartis
PI3K Class 1A
MEK 1/2
Novartis
PI3K Class 1
mTOR Raptor
mTOR Rictor
MEK 1/2
Novartis
PI3K Class 1
MEK 1/2
Hoffman-La Roche
gama-secretase
Novartis
KIT (Gleevec)
PDGFRA (Gleevec)
Bcr-Abl (Gleevec)
PI3K (BKM120)
Novartis + GlaxoSmithKline
MEK 1/2
PI3K Class 1A
Pfizer
Pfizer
Pfizer
EMD Serono
EMD Serono
Genentech
Genentech
Bayer
PI3K
Bayer
MEK
Bayer
PI3K
MEK
Novartis
Bristol-Myers Squibb
LAG-3
Incyte
IDO1
Cornerstone Pharmaceuticals
α-ketoglutarate dehydrogenase (KGDH)
Pyruvate dehydrogenase (PDH)
Novartis
FGFR
FGFR1
FGFR2
FGFR3
Novartis
KIT (imatinib)
FGFR
Boston Biomedical
NANOG
Novartis
KIT
Genentech
IDO1
Cogent Biosciences
KIT
Novartis
PD-1
ISA Pharmaceuticals
Novartis
Stanford University
CD47
Kolltan
Kit
ArQule
AKT
BerGenBio
AXL
Xencor
SSTR2
CD3
Peloton
HIF-2a
Amgen
KRAS G12C
Taiho Pharmaceuticals
HSP90 subtype alpha HSP90 subtype beta
CStone Pharmaceuticals
PD-L1

249 drugs found

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