Drug: |
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Trial Name: |
Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas |
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NCT#: |
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Conditions: |
Gastrointestinal Stromal Tumor |
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Status: |
Recruiting |
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Phase: |
1 |
Start Date 10/10/2018 |
Age of Trial (yrs) 5.1 |
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Treatment Phase: |
Gleevec-resistant |
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Drug Category: |
SDH-directed |
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Strategy: |
Damage DNA and activate cell death receptor |
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Trial Type: |
Specifically GIST plus other cancers |
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Other Protocol IDs: |
Ph1 INBRX-109 |
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Sponsor: |
Inhibrx, Inc. |
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Patient Contact: |
Miranda Fox, Trial Manager
858-500-7833
clinicaltrials@inhibrx.com
Kevin Bayer, Clinical Director
clinicaltrials@inhibrx.com |
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Contact email: |
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Contact Phone: |
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Randomized: |
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IV or Oral: |
Oral
Intravenous |
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Trial Notes: |
Partial Criteria 10/8/2022. Check NCT listing for full criteria. Inclusion Criteria: Escalation: Histologically or cytologically-confirmed advanced/metastatic or non-resectable solid tumors, including sarcoma, that are refractory or intolerant to standard therapy, or for which no standard therapy exists that is likely to confer any clinical benefit. Expansion Cohorts: Malignant pleural mesothelioma, gastric adenocarcinoma, colorectal adenocarcinoma, pancreatic adenocarcinoma and certain sarcoma subtypes (e.g., chondrosarcoma, Ewing sarcoma), GIST, and SDH-def solid tumors with locally advanced or metastatic, non-resectable disease, that are refractory or intolerant to standard therapy, or for which no standard therapy exists that is likely to confer any clinical benefit. Measurable disease as defined by RECISTv1.1 (or modified RECIST for mesothelioma) criteria. Adequate hematologic, coagulation, hepatic and renal function as defined per protocol. Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 or 1 for Part 1 and ECOG PS of 0, 1 or 2 for Parts 2 and 3. Exclusion Criteria: Prior treatment with or exposure to DR5 agonists. |
Trial Links |
Trial Results |
Drug Information |
Name |
Address |
City |
State |
Zip |
Country |
10460 N. 92nd St. |
Scottsdale |
AZ |
85258 |
USA |
|
1500 E. Duarte Road |
Duarte |
CA |
91010 |
USA |
|
2811 Wilshire Blvd |
Santa Monica |
CA |
90403 |
USA |
|
1665 N. Ursula St. |
Aurora |
CO |
80045 |
USA |
|
1365C Clifton Road |
Atlanta |
GA |
30322 |
USA |
|
5841 S. Maryland Ave |
Chicago |
IL |
60637 |
USA |
|
1500 East Medical Center Dr |
Ann Arbor |
MI |
48109 |
USA |
|
Cleveland |
OH |
44195 |
USA |
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38th and Walnut Streets |
Philadelphia |
PA |
19104 |
USA |
|
1505 Holcombe Blvd. |
Houston |
TX |
77030 |
USA |
|
Fairfax |
VA |
22031 |
USA |
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1275 York Ave |
New York |
NY |
10065 |
USA |
|
Grand Rapids |
MI |
49546 |
USA |
||
Fairfax |
VA |
22031 |
USA |
||
2080 Century Park E |
Los Angeles |
CA |
90067 |
USA |
|
3181 S.W. Sam Jackson Park Rd. |
Portland |
OR |
97239 |
USA |