Drug: |
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Trial Name: |
A Study of HQP1351 in Patients With GIST or Other Solid Tumors |
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NCT#: |
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Conditions: |
Solid Tumors |
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Status: |
Recruiting |
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Phase: |
1 |
Start Date 07/11/2018 |
Age of Trial (yrs) 5.2 |
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Treatment Phase: |
Gleevec-resistant |
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Drug Category: |
KIT inhibitor |
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Strategy: |
Block KIT |
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Trial Type: |
Specifically GIST plus other cancers |
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Other Protocol IDs: |
SJ-0003 |
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Sponsor: |
Ascentage Pharma Group Inc. |
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Patient Contact: |
Yifan Zhai, M.D., Ph.D.
+86-20-28069260
yzhai@ascentagepharma.com |
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Contact email: |
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Contact Phone: |
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Randomized: |
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IV or Oral: |
Oral |
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Trial Notes: |
Detailed Description: The primary objective of this phase 1 study is to determine the RP2D of HQP1351 in patients with GIST or other solid tumors. The secondary objective is to assess the safety, tolerability, PK and preliminary anti-tumor activities of HQP1351 in Patients With GIST or Other Solid Tumors. Criteria Inclusion Criteria: Male or not pregnant or lactating women, ageā„12years. Advanced and/or metastatic GIST or other solid tumors, confirmed by histology and/or cytology. GIST patients must be primary resistant to imatinib (tumor progresses within 6 months first-line imatinib treatment, or succinate dehydrogenase B (SDHB) deficient confirmed by immunohistochemistry, or NF1 mutation), OR imatinib or imatinib and at least one other TKI treatment failure (after imatinib or other TKI treatment for more than 6 months, tumor progress again after achieving tumor remission or stability). |
Trial Links |
Trial Results |
Drug Information |
Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors. |
Name |
Address |
City |
State |
Zip |
Country |
Guangzhou |
Guandong |
510060 |
China |
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Guangzhou |
Guangdong |
China |
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Wuhan |
Hubei |
215316 |
China |
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Beijing |
China |
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Shanghai |
China |
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Zhengzhou |
Henan |
China |