Drug: |
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Trial Name: |
Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumor |
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NCT#: |
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Conditions: |
Gastrointestinal Stromal Tumor |
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Status: |
Recruiting |
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Phase: |
2 |
Start Date 09/06/2023 |
Age of Trial (yrs) 1.6 |
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Treatment Phase: |
Gleevec-resistant |
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Drug Category: |
VEGFR inhibitor + Microtubule stabilizer |
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Strategy: |
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Trial Type: |
Specifically GIST and only GIST |
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Other Protocol IDs: |
AMC2301 |
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Sponsor: |
Asan Medical Center |
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Patient Contact: |
Study Contact:
Ryu Min-Hee, MD, PhD
82-2-3010-5935
miniryu@amc.seoul.kr
Study Contact Backup
Kim Hyung-Don, MD, PhD
82-2-3010-0236
kimhdmd@amc.seoul.k
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Contact email: |
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Contact Phone: |
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Randomized: |
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IV or Oral: |
Oral
Intravenous |
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Trial Notes: |
A Phase 2 Study of Paclitaxel Plus Rivoceranib in Patients With GIST With a High P-glycoprotein Expression After Failure With at Least Imatinib, Sunitinib and Regorafenib Partial Eligibility Criteria. See NCT listing for all eligibility criteria. Description Inclusion Criteria: Age 20 years or older, at the time of acquisition of informed consent Histologically confirmed metastatic and/or advanced GIST with CD117(+), DOG-1(+), or mutation in KIT or PDGFRα gene P-glycoprotin IHC score > 3 (Tumor tissue with disease progression after regorafenib treatment) Failed (progressed and/or intolerable) after prior treatments for GIST, including at least imatinib and sunitinib, regorafenib. |
Trial Links |
Trial Results |
Drug Information |
Name |
Address |
City |
State |
Zip |
Country |
Seoul |
Songpa-gu |
138-736 |
Republic of Korea |