TRIAL DETAIL

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Drug:
Trial Name:
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)
NCT#:
Conditions:
Gastrointestinal Stromal Tumor
Status:
Recruiting
Phase:
2
Start Date 08/12/2021
Age of Trial (yrs) 2.6
Treatment Phase:
Gleevec-resistant
Drug Category:
SDH-directed
Strategy:
HIF-2a inhibitor
Trial Type:
Specifically GIST plus other cancers
Other Protocol IDs:
6482-015 MK-6482-015 ( Other Identifier: Merck ) PT2977 ( Other Identifier: Former name ) jRCT2011220024 ( Registry Identifier: Japan Registry of Clinical Trials (jRCT) ) 2023-504853-11-00 ( Registry Identifier: EU CT ) 2020-005028-13 ( EudraCT Number )
Sponsor:
Merck Sharp & Dohme LLC
Patient Contact:
1-888-577-8839 Trialsites@merck.com
Contact email:
Contact Phone:
Randomized:
IV or Oral:
Oral
Trial Notes:
Inclusion Criteria: Partial

For Cohort C participants with GIST (wt):

Has documented histopathological diagnosis of GIST.
Local test report documenting the absence of sensitizing mutations in both platelet derived growth factor receptor alpha (PDGFRA) and receptor tyrosine kinase (c-KIT).
Has locally advanced or metastatic disease that is not amenable to surgery or curative intent treatment.

Trial Links

 

Trial Results

Drug Information

Wikipedia
 

Trial Sites

Name
Address
City
State
Zip
Country
8700 Beverly Blvd.
Los Angeles
CA
90048
USA
Iowa City
IA
52242
USA
1500 East Medical Center Dr
Ann Arbor
MI
48109
USA
660 S. Euclid Ave
St. Louis
MO
63110
USA
New York
NY
10029
USA
38th and Walnut Streets
Philadelphia
PA
19104
USA
2220 Pierce Ave.
Nashville
TN
37232
USA
1505 Holcombe Blvd.
Houston
TX
77030
USA
Beijing
Beijing
100034
China
Barker Street
Randwick
New South Wales
2031
Australia
Grattan Street
Parkville
Victoria
3050
Australia
Calgary
AB
T2N 4N2
Canada
610 University Ave
Toronto
ON
M5G 2M9
Canada
Guangzhou
Guandong
510000
China
Strasbourg
67098
France
Marseille
Bouches du Rhone
13273
France
Villejuif
Val de Narne
94805
France
Lyon
69008
France
Breisacher Straße 117
Freiburg
D-79106
Germany
Berlin
10115
Germany
Milano
Italy
Hokkaido
Japan
Heidelberglaan 100
Utrecht
3584 CX
Netherlands
Singapore
Singapore
Madrid
Spain
119-129
Barcelona
08035
Spain
Lund
SE-221 85
Sweden
Uppsala
SE-751 85
Sweden
Glasgow
G12 0YN
UK
Baltimore
MD
21231
USA
Rahat
52621
Israel
Verona
31726
Italy
Chuo-ku
Tokyo
104-0045
Japan
Solna
SE-171 76
Sweden
Gothenburg
SE-413 45
Sweden
Cambridge
CB2 OQQ
UK
55 Fruit Street
Boston
MA
02114
USA
Shanghai
Shanghai
200127
China
Cheng Du
Sichaun
610041
China
Copenhagen
Hovedstaden
2100
Denmark
Odense
Syddanmark
5000
Denmark
Paris
94270
France
Paris
75679
France
Munchen
Bayern
80336
Germany
Wurzburg
Bayern
97080
Germany
Budapest
1083
Hungary
Naples
Campania
80100
Italy
Milano
Lombardia
20132
Italy
Brescia
25123
Italy
Yokohama
Kanagawa
2360004
Japan
Nankoku
Kochi
783-0505
Japan
Kyoto
Japan
Tokyo
123-8558
Japan
Oviedo
Asturias
33011
Spain
Madrid
Madrid
28033
Spain
Bornova
Izmir
35100
Turkey
Ankara
06230
Turkey
Ankara
06800
Turkey
Istanbul
34668
Turkey
London
England
NW3 2QG
UK
London
W12 0HS
UK