Drug: |
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Trial Name: |
Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015) |
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NCT#: |
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Conditions: |
Gastrointestinal Stromal Tumor |
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Status: |
Recruiting |
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Phase: |
2 |
Start Date 08/12/2021 |
Age of Trial (yrs) 1.8 |
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Treatment Phase: |
Gleevec-resistant |
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Drug Category: |
SDH-directed |
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Strategy: |
HIF-2a inhibitor |
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Trial Type: |
Specifically GIST plus other cancers |
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Other Protocol IDs: |
6482-015
MK-6482-015 ( Other Identifier: Merck )
PT2977 ( Other Identifier: Former name )
jRCT2011220024 ( Registry Identifier: Japan Registry of Clinical Trials (jRCT) )
2023-504853-11-00 ( Registry Identifier: EU CT )
2020-005028-13 ( EudraCT Number ) |
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Sponsor: |
Merck Sharp & Dohme LLC |
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Patient Contact: |
1-888-577-8839 Trialsites@merck.com |
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Contact email: |
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Contact Phone: |
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Randomized: |
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IV or Oral: |
Oral |
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Trial Notes: |
Inclusion Criteria: Partial For Cohort C participants with GIST (wt): Has documented histopathological diagnosis of GIST. Local test report documenting the absence of sensitizing mutations in both platelet derived growth factor receptor alpha (PDGFRA) and receptor tyrosine kinase (c-KIT). Has locally advanced or metastatic disease that is not amenable to surgery or curative intent treatment. |
Trial Links |
Trial Results |
Drug Information |
Wikipedia |
Name |
Address |
City |
State |
Zip |
Country |
8700 Beverly Blvd. |
Los Angeles |
CA |
90048 |
USA |
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Iowa City |
IA |
52242 |
USA |
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1500 East Medical Center Dr |
Ann Arbor |
MI |
48109 |
USA |
|
660 S. Euclid Ave |
St. Louis |
MO |
63110 |
USA |
|
New York |
NY |
10029 |
USA |
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38th and Walnut Streets |
Philadelphia |
PA |
19104 |
USA |
|
2220 Pierce Ave. |
Nashville |
TN |
37232 |
USA |
|
1505 Holcombe Blvd. |
Houston |
TX |
77030 |
USA |
|
Barker Street |
Randwick |
New South Wales |
2031 |
Australia |
|
Grattan Street |
Parkville |
Victoria |
3050 |
Australia |
|
Calgary |
AB |
T2N 4N2 |
Canada |
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610 University Ave |
Toronto |
ON |
M5G 2M9 |
Canada |
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Guangzhou |
Guandong |
510060 |
China |
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Strasbourg |
67098 |
France |
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Marseille |
Bouches du Rhone |
13273 |
France |
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Villejuif |
Val de Narne |
94805 |
France |
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Lyon |
69008 |
France |
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Breisacher Straße 117 |
Freiburg |
D-79106 |
Germany |
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Berlin |
10115 |
Germany |
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Milano |
Italy |
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Hokkaido |
Japan |
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Heidelberglaan 100 |
Utrecht |
3584 CX |
Netherlands |
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Singapore |
Singapore |
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Madrid |
Spain |
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119-129 |
Barcelona |
08035 |
Spain |
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Lund |
SE-221 85 |
Sweden |
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Uppsala |
SE-751 85 |
Sweden |
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Glasgow |
G12 0YN |
UK |