TRIAL DETAIL

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Drug:
Trial Name:
Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis
NCT#:
Conditions:
Gastrointestinal Stromal Tumor
Status:
Recruiting
Phase:
Start Date 12/18/2020
Age of Trial (yrs) .8
Treatment Phase:
All Gleevec-resistant Adjuvant Neoadjuvant First-line Stable disease
Drug Category:
None
Strategy:
Radiation
Trial Type:
Specifically GIST and only GIST
Other Protocol IDs:
200161 20-C-0161
Sponsor:
National Cancer Institute
Patient Contact:
Audra A Satterwhite, R.N. (240) 858-3552 audra.satterwhite@nih.gov
Contact email:
Contact Phone:
Randomized:
IV or Oral:
Trial Notes:
Observational, prospective surgery trial.
Will admit international patients
INCLUSION CRITERIA:
Histological confirmation or clinical presentation suspicious of GIST; histological confirmation will be preferably by review of archival tissue if available, fresh biopsy will not be required if inadequate tissue sample.
Age >= 6 years
ECOG performance status <= 2 (Karnofsky or Lansky >= 60%)
Ability of participant or parent/guardian to understand and the willingness to sign a written informed consent document.
Ability and willingness to enroll on 13C0176, "Tumor, Normal Tissue and Specimens from Patients Undergoing Evaluation or Surgical Resection of Solid Tumors".

EXCLUSION CRITERIA:

- Non-modifiable medical comorbidities that would preclude cytoreductive surgery.

Brief Summary:

Objective:

To follow people with GISTs and collect tumor tissue so that it can be studied in the lab.

Eligibility:

People age 6 and older who have a GIST.

Design:

Participants will be screened with a review of their medical records and samples.

Participants will enroll in 3 other NIH studies.

Participants will have a medical history and physical exam. Data about how they function in their daily activities will be obtained.

Participants may speak with a genetic counselor. They may have genetic testing.

Participants will give blood samples. They may have a cheek swab. For this, small brush will be rubbed against the inside of the cheek.

Participants may have a computed tomography (CT) scan of the chest, abdomen, and pelvis. Or they may have a CT scan of the chest and magnetic resonance imaging (MRI) of the abdomen and pelvis.

Participants will be monitored every 6-12 months at the NIH Clinical Center, for up to 10 years before having surgery. If they need surgery, it will be performed at the NIH. Then, they will be monitored every 6-12 months, for up to 5 years after surgery.

If a participant has surgery, tumor tissue samples will be taken.

If a participant does not need surgery, their participation will end after 10 years. If they have surgery, the 5-year monitoring period will restart after each surgery.

Trial Links

 

Trial Results

Drug Information

Trial Sites

Name
Address
City
State
Zip
Country
Building 10, Room 4-3760
Bethesda
MD
20892
USA