TRIAL DETAIL
A Study to Evaluate the Safety and Pharmacokinetics of KTN0158 in Adult Patients With Advanced Solid Tumors
Drug: |
||||
|---|---|---|---|---|
Trial Name: |
A Study to Evaluate the Safety and Pharmacokinetics of KTN0158 in Adult Patients With Advanced Solid Tumors |
|||
NCT#: |
||||
Conditions: |
Any type of Cancer |
|||
Status: |
Ongoing, but not recruiting |
|||
Phase: |
1 |
Start Date 12/01/2015 |
Age of Trial (yrs) 8.4 |
|
Treatment Phase: |
Gleevec-resistant |
|||
Drug Category: |
KIT/PDGFRA inhibitor |
|||
Strategy: |
Block KIT + Stimulate the immune system |
|||
Trial Type: |
Specifically GIST plus other cancers |
|||
Other Protocol IDs: |
KTN0158-CL-001 |
|||
Sponsor: |
Koltan Pharmaceuticas |
|||
Patient Contact: |
Lisa Kamen, MHA
203-907-0958
lisa.kamen@kolltan.com |
|||
Contact email: |
||||
Contact Phone: |
||||
Randomized: |
||||
IV or Oral: |
Intravenous |
|||
Trial Notes: |
This is a dose-escalation Phase 1 study designed to determine the maximum tolerated dose (MTD) and/or recommended Phase 2 dose, and the safety profile of KTN0158 in patients with KIT-positive advanced solid malignancies refractory to standard therapy or for which no standard therapy exists. Inclusion criteria: 3. For patients with GIST, patients will have progressed on at least one prior tyrosine kinase inhibitor therapy or be intolerant. If documented to have SDH deficient or PDGFRA-D842V GIST, no prior therapy is required for study entry. |
|||
Trial Links |
Trial Results |
Drug Information |
| Kolltan Pharmaceuticals Provides Update on Clinical Pipeline, Corporate Developments and Near-Term Milestones 1/8/2016 |
Trial Sites
Name |
Address |
City |
State |
Zip |
Country |
3322 West End Avenue |
Nashville |
TN |
37203 |
USA |
|
450 Brookline Ave |
Boston |
MA |
02215-5450 |
USA |
|
3181 S.W. Sam Jackson Park Rd. |
Portland |
OR |
97239 |
USA |
|
55 Fruit Street |
Boston |
MA |
02114 |
USA |