TRIAL DETAIL

A Phase 1b Study of MPDL3280A (an Engineered Anti-PDL1 Antibody) in Combination With Cobimetinib in Patients With Locally Advanced or Metastatic Solid Tumors

Drug:
Trial Name:
A Phase 1b Study of MPDL3280A (an Engineered Anti-PDL1 Antibody) in Combination With Cobimetinib in Patients With Locally Advanced or Metastatic Solid Tumors
NCT#:
Conditions:
Solid Tumors
Status:
Ongoing, but not recruiting
Phase:
1
Start Date 12/01/2013
Age of Trial (yrs) 8
Treatment Phase:
Gleevec-resistant
Drug Category:
MEK inhibitor + PD-L1 inhibitor
Strategy:
Block related tumor path + stimulate immune system
Trial Type:
GIST not specified. GIST patients known to be enrolled.
Other Protocol IDs:
GP28363
Sponsor:
Hoffmann-La Roche
Patient Contact:
Reference Study ID Number: GP28363 www.roche.com/about_roche/roche_worldwide.htm 888-662-6728 (U.S. Only) global rochegenentechtrials@roche.com
Contact email:
Contact Phone:
Randomized:
IV or Oral:
Oral Intravenous
Trial Notes:
A Phase Ib, open-label, multicenter study designed to assess the safety, tolerability, and pharmacokinetics of coadministration of MPDL3280A and of cobimetinib in patients with metastatic or locally advanced cancer for which no standard of care exists.

Trial Links

Trial Results

Drug Information

Trial Sites

Name
Address
City
State
Zip
Country
Palo Alto
CA
94304
USA
333 Cedar St
New Haven
CT
06510
USA
450 Brookline Ave
Boston
MA
02215-5450
USA
100 Blossom St
Charlestown
MA
02114
USA
New York
NY
10065
USA
Tyler
TX
75702
USA
1 Arnold Street
Box Hill
Victoria
3128
Australia
Grattan Street
Parkville
Victoria
3050
Australia
610 University Ave
Toronto
ON
M5G 2M9
Canada
Montreal
QC
H3T 1E2
Canada
Montreal
QC
H2L 4M1
Canada
Breisacher Stra├če 117
Freiburg
D-79106
Germany
101 DAEHAK-RO
Seoul
110-774
Republic of Korea
Seoul
Songpa-gu
138-736
Republic of Korea
Singapore
119074
Singapore
Seattle
WA
98195
USA
Vancouver
WA
98684
USA
Denver
CO
80220
USA
Chapel Hill
NC
27599
USA
Nashville
TN
37203
USA
Arlington
TX
76012
USA
Dresden
01307
Germany
Singapore
188770
Singapore