Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (ImadGist)

Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST) (ImadGist)

Gastrointestinal Stromal Tumor

Recruiting

3

Start Date 12/24/2014

Age of Trial (yrs) 9.3

Adjuvant

KIT/PDGFRA inhibitor

Block KIT

Specifically GIST and only GIST

IMADGIST 2013-001372-37 ( EudraCT Number )

Centre Leon Berard

Jean-Yves Blay, Pr +33 4 78 78 27 57 jean-yves.blay@lyon.unicancer.fr

Randomized

Oral

This is a 2 arms study concerning patients with primary GIST who followed an Imatinib adjuvant treatment for 3 years after surgery and who have a high risk of recurrence.

In the first arm, patients will continue Imatinib treatment for 3 more years, allowing to determine if the continuation of this treatment is efficient for disease control, in terms of Disease Free Survival improvement.

In the second arm, patients will discontinue the Imatinib treatment, as standard practice. This arm will allow to determine if the re-introduction of Imatinib at relapse is still an efficient treatment for the control of disease.