Drug: |
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Trial Name: |
Phase ll Study of Imatinib Mesylate for the Neoadjuvant Treatment of Patients With Gastrointestinal Stromal Tumors (GIST) (CONVERT) |
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NCT#: |
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Conditions: |
Gastrointestinal Stromal Tumor |
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Status: |
Completed |
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Phase: |
2 |
Start Date 06/15/2008 |
Age of Trial (yrs) 16.2 |
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Treatment Phase: |
Neoadjuvant |
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Drug Category: |
KIT/PDGFRA inhibitor |
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Strategy: |
Block KIT |
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Trial Type: |
Specifically GIST and only GIST |
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Other Protocol IDs: |
CSTI571BBR10
CONVERT |
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Sponsor: |
Novartis |
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Patient Contact: |
Contact: Novartis Pharmaceuticals +1-862-778-8300
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Contact email: |
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Contact Phone: |
+1-862-778-8300 |
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Randomized: |
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IV or Oral: |
Oral |
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Trial Notes: |
This study will evaluate the efficacy, safety, tolerability of imatinib in the neoadjuvant treatment (pre-operatory) of patients with GIST. It will also evaluate the potential of imatinib to convert a tumor from inoperable to operable. Ages Eligible for Study: 18 Years to 80 Years Genders Eligible for Study: Both Accepts Healthy Volunteers: No Criteria Inclusion Criteria: patients with age between 18 and 80 years diagnosis of GIST not previously treated Patients will be included in the protocol regardless of operability; in the case of an operable tumor, patients are eligible if, in the opinion of the surgeon, resection would be suboptimal, disfiguring or functionally disabling (i.e. incomplete resection or other which cold compromise severely the quality of life or other GI function) Exclusion criteria: presence of metastatic disease use of other antineoplastic treatment (chemotherapy, immunotherapy, radiotherapy) Other protocol-defined inclusion/exclusion criteria may apply. |
Trial Links |
Trial Results |
Name |
Address |
City |
State |
Zip |
Country |
Rio de Janeiro |
Brazil |
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Sao Paulo/SP |
Brazil |
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Porto Alegre |
Brazil |
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Belo Horizonte |
Brazil |
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Florianopolis |
Brazil |