Treatment Response Evaluation in Gastrointestinal Stromal Tumor (GIST) Patients

Treatment Response Evaluation in Gastrointestinal Stromal Tumor (GIST) Patients

Gastrointestinal Stromal Tumor

Completed

4

Start Date 02/01/2011

Age of Trial (yrs) 13.2

All

KIT/PDGFRA inhibitor

Block KIT + Block related tumor signal paths

Specifically GIST and only GIST

REK-2010/2089

Oslo University Hospital

Mona-Elisabeth Revheim, MD +4723070840 mona.elisabeth.revheim@ous-hf.no Therese Seierstad, PhD +4722781237 therese@radium.uio.no

Oral

The purpose of this study is to compare sensitivity, specificity and accuracy of PET, DW MRI and CT separately and combined for the evaluation of treatment response and progression-free survival in patients with GIST.

Study Population

GIST patients suitable for medical treatment with targeted therapies.
Criteria

Inclusion Criteria:

* Metastatic GIST patients suitable for TKI treatment
* GIST patients pursuing preoperative neoadjuvant TKI treatment

Exclusion Criteria:

* Patients with contraindications to MRI and/or TKI treatment. For patients with renal failure, CT without intravenous contrast will be performed according to clinical practice.
* Patients who do not sign the consent paper for any reason or do not accept the study premises or patients who wish to withdraw for any reason during the study