TRIAL DETAIL

Safety Study to Determine the Maximum Tolerated Dose, Pharmacokinetics and Pharmacodynamics of Oral MP470, a Multitargeted Tyrosine Kinase Inhibitor, in Patients With Solid Malignancies

Drug:
Trial Name:
Safety Study to Determine the Maximum Tolerated Dose, Pharmacokinetics and Pharmacodynamics of Oral MP470, a Multitargeted Tyrosine Kinase Inhibitor, in Patients With Solid Malignancies
NCT#:
Conditions:
Solid Tumors
Status:
Ongoing, but not recruiting
Phase:
1
Start Date 05/01/2007
Age of Trial (yrs) 17
Treatment Phase:
Gleevec-resistant
Drug Category:
KIT/PDGFRA inhibitor
Strategy:
Block KIT
Trial Type:
GIST not specified. GIST patients known to be enrolled.
Other Protocol IDs:
SGI-0470-01
Sponsor:
SuperGen Inc.
Patient Contact:
SuperGen Gil Fine, PhD 925-560-0100 gfine@supergen.com Angelique Mittan, CLS 925-560-0100
Contact email:
Contact Phone:
Randomized:
IV or Oral:
Oral
Trial Notes:
This information is from the second ClinicalTrials.gov entry for this trial. See also NCT00504205.

Trial Links

 

Trial Results

 

Drug Information

PDF-MP470, a potent oral Rad51 suppressor is safe and tolerable
 
A novel tyrosine kinase switch is a mechanism of imatinib resistance in GIST
 
AACR-2009- #3873 A TK switch is a mechanism of resistance to c-Kit directed therapies in GIST
 
AACR-2009 #1354 Activated tyrosine kinases in gastrointestinal stromal tumor with loss of KIT oncoprotein expression
 
SuperGen news release: SuperGen's MP-470 demonstrates clinical benefit in lung cancer patients
 
Large list of posters from SuperGen website
 
Press release - Astex Pharmaceuticals Discontinues Amuvatinib Clinical Development Program
 
Novel receptor tyrosine kinase targeted combination therapies for imatinib-resistant gastrointestinal stromal tumors (GIST).
 

Trial Sites

Name
Address
City
State
Zip
Country
10460 N. 92nd Street, Suite 206
Scottsdale
AZ
85248
USA
4319 Medical Dr.
San Antonio
TX
78229
USA