A Phase I Open Label, Safety, Pharmacokinetic and Pharmacodynamic Dose Escalation Study in SF1126, a PI Kinase (PI3K) Inhibitor, Given Twice Weekly by IV Infusion to Patients With Advanced or Metastatic Tumors

A Phase I Open Label, Safety, Pharmacokinetic and Pharmacodynamic Dose Escalation Study in SF1126, a PI Kinase (PI3K) Inhibitor, Given Twice Weekly by IV Infusion to Patients With Advanced or Metastatic Tumors

Solid Tumors

Ongoing, but not recruiting

1

Start Date 04/01/2007

Age of Trial (yrs) 18

Gleevec-resistant

PI3K inhibitor

Block KIT Signal Path

Specifically GIST plus other cancers

SF1126-001-06

Semafore Pharmaceuticals

See site contact info below

Intravenous

Semafore Pharmaceuticals, a small company in Indianapolis, Ind. has developed a broad spectrum PI3K inhibitor based on the lab drug LY294002. SF1126 is a Prodrug that inhibits Class IA PI3Ks and DNA-PK and mTOR. A Prodrug is given in one form and converted into a different, active form by metabolic action in the body. Semafore has designed SF1126 to have an affinity for the vascular forming areas of tumors.